The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites
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Founder populations are populations that are derived from a well-defined ancestral population with little admixture since their founding. Founder populations can be old and derived from a larger number of ancestors, such as the Finnish, Icelandic, Ashkenazi, and Sardinian populations, or young and derived from a much smaller number of founders, such as the Amish, Hutterites, and Tristan de Cunhans . The latter group of founder populations is also inbred, i.e., the inbreeding coefficient is > 0 for nearly everyone in the population because all matings are consanguineous.
KeywordsHuman Leukocyte Antigen Susceptibility Allele Founder Population Linkage Disequilibrium Mapping Outbred Population
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