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The Many Faces of Osteoarthritis pp 131–146Cite as

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Hyaluronics and aggrecanics

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Abstract

Hyaluronan (HA) is a high molecular weight (105-107Da) unbranched glycosaminoglycan, composed of repeating disaccharides of D-N-Acetylglucosamine and D-Glucuronic acid. It is a widely distributed component of the extracellular matrix of vertebrate tissues [1]. It also acts as a scaffold for the binding of selected matrix molecules including aggrecan and other members of the hyalectan family [2, 3]. HA forms viscoelastic solutions and there is much interest and speculation on the properties that contribute to its pronounced non-Newtonian behaviour.

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Author information

Authors and Affiliations

  1. Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK

    Tim Hardingham

Authors
  1. Tim Hardingham
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, The Cleveland Clinic Foundation, Orthopaedic Research Center, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Vincent C. Hascall

  2. Department of Biochemistry, Rush Medical College at Rush Presbyterian-St. Luke’s Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612-3864, USA

    Klaus E. Kuettner

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© 2002 Springer Basel AG

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Hardingham, T. (2002). Hyaluronics and aggrecanics. In: Hascall, V.C., Kuettner, K.E. (eds) The Many Faces of Osteoarthritis. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8133-3_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8133-3_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9450-0

  • Online ISBN: 978-3-0348-8133-3

  • eBook Packages: Springer Book Archive

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