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Toll-like receptors and the cardiovascular system

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Book cover Inflammation and Cardiac Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Most micro-organisms that are encountered daily by a healthy individual are detected initially by defense mechanisms that are not antigen-specific, a response that is mediated by the innate immune system. In contrast to the adaptive immunity, where specific antigen receptors are generated by somatic hypermutation and selection, the innate immune systems uses germline encoded proteins that recognize specific patterns shared by groups of pathogens, but not the host. These receptors are called “pattern recognition receptors” (“PRRs”) and recognize largely invariant “pathogen-associated molecular patterns” (“PAMPs”), as for example lipopolysaccharides of bacteria or double-stranded RNA of viruses [1]. This review will focus on the toll-like receptor (TLR) family, a class of pattern recognition receptors of major importance [2].

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Authors and Affiliations

  1. Medizinische Universitätsklinik Würzburg, Josef-Schneider-Str. 2, Würzburg, 97080, Germany

    Stefan Frantz

  2. Genzyme Corporation, 15 Pleasant St, Connector, P.O. Box 9322, Framingham, MA, 01701-9322, USA

    Ralph A. Kelly

  3. Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Todd Bourcier

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  1. Stefan Frantz
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  2. Ralph A. Kelly
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  3. Todd Bourcier
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Editors and Affiliations

  1. Pharmacology Department WP42-209, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, USA

    Giora Z. Feuerstein

  2. Cardiovascular Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue EBRC 307, Boston, MA, 02115, USA

    Peter Libby

  3. Winters Center for Heart Failure Research, 6565 Fannin MS 524, Houston, TX, 77030, USA

    Douglas L. Mann

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Frantz, S., Kelly, R.A., Bourcier, T. (2003). Toll-like receptors and the cardiovascular system. In: Feuerstein, G.Z., Libby, P., Mann, D.L. (eds) Inflammation and Cardiac Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8047-3_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8047-3_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9419-7

  • Online ISBN: 978-3-0348-8047-3

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