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Heat shock proteins in immune response

  • Chapter
Heat Shock Proteins and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The connection between HSPs and tumor rejection antigens became apparent through tumor rejection studies in mice and rats. In search for individually distinct tumor rejection antigens, tumor cell lysates were fractionated biochemically and each fraction was tested for its ability to immunize in vivo against the tumor. The tumor rejection antigens thus found were mostly HSPs (Tab. 1). Preparations of HSPs, e.g., HSP70, HSP90, gp96 and calreticulin (CRT) from Meth A fibrosarcoma (tumor induced in BALB/c mice by methylcholanthrene) when used to immunize BALB/c mice, rendered the mice immune to subsequent challenge with live Meth A tumor cells in a classical tumor rejection assay [1-3]. However, immunization of mice with HSP preparations from normal tissues [2] or from antigenically-distinct tumor cells [1, 4] did not protect the animals against tumor challenge.

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Authors and Affiliations

  1. Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, MC1601, Farmington, CT, 06030-1601, USA

    Sreyashi Basu & Pramod Srivastava

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  1. Sreyashi Basu
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  2. Pramod Srivastava
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Editors and Affiliations

  1. Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1, Utrecht, 3584CL, The Netherlands

    Willem van Eden

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Basu, S., Srivastava, P. (2003). Heat shock proteins in immune response. In: van Eden, W. (eds) Heat Shock Proteins and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8028-2_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8028-2_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9410-4

  • Online ISBN: 978-3-0348-8028-2

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