Abstract
This chapter positions HSP60 at the center of inflammation and body maintenance. We shall discuss the following topics:
-
Inflammation: Physiological
-
Inflammation: Pathological - HSP60: Autoimmune target
-
HSP60: Regulator signal
-
HSP60: Innate ligand
-
HSP60 model
-
Signal fidelity and HSP60
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Parnes O (2003) “Trouble from within”: Allergy, autoimmunity and pathology in the first half of the twentieth century. Studies in History and Philosophy of Biological and Biomedical Sciences; in press
Florey L (1970) General pathology. 4th ed, Lloyd-Luke medical books, London
Ebert RH (1965) The inflammatory process. In: BW Zweifach, L Grant, RT McCluskey (eds): The Inflammatory Process. Academic Press, New York, 1–7
Schwartz M, Cohen IR (2000) Autoimmunity can benefit self-maintenance. Immunol Today 21: 265–268
Cohen IR (2000) Discrimination and dialogue in the immune system. Semin Immunol 12: 215–219; discussion 257–344
Cohen IR (2000) Tending Adam’s garden: Evolving the cognitive immune self. Academic Press, London
Cohen IR, Efroni S (2003) Inflammation and vaccination: Cause and cure for Type 1 diabetes. In: I Raz, JS Skyler, E Shafir (eds): Diabetes: From research to diagnosis and treatment. Martin Dunitz, London, 223–233
Calandra T, Bochud PY, Heumann D (2002) Cytokines in septic shock. Curr Clin Top Infect Dis 22: 1–23
Wick G, Perschinka H, Millonig G (2001) Atherosclerosis as an autoimmune disease: An update. Trends Immunol 22: 665–669
Abbas AK, Lichtman AH, Pober JS (1994) Cellular and molecular immunology. 2nd ed. WB Saunders Company, Philadelphia
Sidell FR, Franz DR (1997) Overview: defense against the effects of chemical and biological warfare agents. In: FR Sidell, ET Takafuji, DR Franz (eds): Medical Aspects of Chemical and Biological Warfare. Office of The Surgeon General, Washington, D.C., 2–7
Efroni S, Cohen IR (2002) Simplicity belies a complex system: A response to the minimal model of immunity of Langman and Cohn. Cell Immunol 216: 23–30
Bresnihan B (1999) Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol 26: 717–719
Bertinotti L, Miniati I, Cerinic MM (2002) Angioedema and systemic sclerosis. A review of the literature. Scand J Rheumatol 31: 178–180
Feman SS (1997) New discoveries in diabetes-and thyroid-related eye disease. Curr Opin Ophthalmol 8: 61–65
Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD (1997) The codependence of angiogenesis and chronic inflammation. FASEB J 11: 457–465
Hartl FU, Hayer-Hartl M (2002) Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 295: 1852–1858
Zinsmaier KE, Bronk P (2001) Molecular chaperones and the regulation of neurotransmitter exocytosis. Biochem Pharmacol 62: 1–11
Young DB, Ivanyi J, Cox JH, Lamb JR (1987) The 65 kDa antigen of mycobacteria - A common bacterial protein? Immunol Today 8: 215–219
Hansen K, Bangsborg JM, Fjordvang H, Pedersen NS, Hindersson P (1988) Immunochemical characterization of and isolation of the gene for a Borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of bacteria. Infect Immun 56: 2047–2053
Morrison RP, Belland RJ, Lyng K, Caldwell HD (1989) Chlamydial disease pathogenesis. The 57 kD chlamydial hypersensitivity antigen is a stress response protein. J Exp Med 170: 1271–1283
Lamb JR, Young DB (1990) T-cell recognition of stress proteins. A link between infectious and autoimmune disease. Mol Biol Med 7: 311–321
Lamb JR, Bal V, Rothbard JB, Mehlert A, Mendez-Samperio P, Young DB (1989) The mycobacterial GroEL stress protein: A common target of T-cell recognition in infection and autoimmunity. J Autoimmun 2 (Suppl): 93–100
Wauben MHM, Wagenaar-Hilbers JPA, van Eden W (1994) Adjuvant arthritis. In: IR Cohen, A Miller (eds): Autoimmune disease models. Academic Press Inc., San Diego, California, USA
Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest 73: 211–215
van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR (1985) Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci USA 82: 5117–5120
van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, Cohen IR (1988) Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331: 171–173
Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR (1999) T-cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Autoimmun 12: 121–129
Birk OS, Elias D, Weiss AS, Rosen A, van-der Zee R, Walker MD, Cohen IR (1996) NOD mouse diabetes: The ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T-cells. J Autoimmun 9: 159–166
Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR (1991) Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 88: 3088–3091
Elias D, Marcus H, Reshef T, Ablamunits V, Cohen IR (1995) Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein. Eur J Immunol 25: 2851–2857
Cohen IR (1991) Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. Annu Rev Immunol 9: 567–589
Wick G (2000) Atherosclerosis - an autoimmune disease due to an immune reaction against heat-shock protein 60. Herz 25: 87–90
Lehner T (1997) The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behcet’s disease. Int Rev Immunol 14: 21–32
Dhillon V, Latchman D, Isenberg D (1991) Heat shock proteins and systemic lupus erythematosus. Lupus 1: 3–8
Billingham ME, Carney S, Butler R, Colston MJ (1990) A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J Exp Med 171: 339–344
Yang XD, Gasser J, Feige U (1992) Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: Specificity and mechanism. Clin Exp Immunol 87: 99–104
Elias D, Cohen IR (1994) Peptide therapy for diabetes in NOD mice. Lancet 343: 704–706
Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR (1997) Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 46: 758–764
Bockova J, Elias D, Cohen IR (1997) Treatment of NOD diabetes with a novel peptide of the hsp60 molecule induces Th2-type antibodies. J Autoimmun 10: 323–329
Yasunami R, Bach JF (1988) Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur J Immunol 18: 481–484
Quintana FJ, Carmi P, Cohen IR (2002) DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J Immunol 169: 6030–6035
Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR (2001) Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial. Lancet 358: 1749–1753
Birk OS, Gur SL, Elias D, Margalit R, Mor F, Carmi P, Bockova J, Altmann DM, Cohen IR (1999) The 60-kDa heat shock protein modulates allograft rejection. Proc Natl Acad Sci USA 96: 5159–5163
Hogervorst EJ, Schouls L, Wagenaar JP, Boog CJ, Spaan WJ, van Embden JD, van Eden W (1991) Modulation of experimental autoimmunity: Treatment of adjuvant arthritis by immunization with a recombinant Vaccinia virus. Infect Immun 59: 2029–2035
van Eden W, Wendling U, Paul L, Prakken B, van Kooten P, van der Zee R (2000) Arthritis protective regulatory potential of self-heat shock protein cross-reactive T-cells. Cell Stress Chaperones 5: 452–457
Quintana FJ, Carmi P, Mor F, Cohen IR (2002) Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J Immunol 169: 3422–3428
Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2: 675–680
Kol A, Lichtman AH, Finberg RW, Libby P, Kurt-Jones EA (2000) Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J Immunol 164: 13–17
Ohashi K, Burkart V, Flohe S, Kolb H (2000) Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164: 558–561
Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H (2001) Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 276: 31332–31339
Habich C, Baumgart K, Kolb H, Burkart V (2002) The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins. J Immunol 168: 569–576
Habich C, Kempe K, van der Zee R, Burkart V, Kolb H (2003) Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages. FEBS Lett 533: 105–109
Flohe SB, Bruggemann J, Lendemans S, Nikulina M, Meierhoff G, Flohe S, Kolb H (2003) Human heat shock protein 60 induces maturation of dendritic cells versus a Th1- promoting phenotype. J Immunol 170: 2340–2348
Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR (1990) Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 87: 1576–1580
Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider 0 (2003) T-cells respond to heat Shock Protein 60 via TLR-2: Activation of adhesion and inhibition of chemokine receptors. FASEB J 11: 1567–1569
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K et al (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740–745
Quintana FJ, Rotem A, Carmi P, Cohen IR (2000) Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in non-obese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol 165: 6148–6155
Cohen IR (1992) The cognitive paradigm and the immunological homunculus. Immunol Today 13: 490–494
Zehavi A (1997) The handicap principle: A missing piece of Darwin’s puzzle. Oxford University Press, London
Macario AJ, Lange M, Ahring BK, De Macario EC (1999) Stress genes and proteins in the archaea. Microbiol Mol Biol Rev 63: 923–967
Imler JL, Hoffmann JA (2002) Toll receptors in Drosophila: A family of molecules regulating development and immunity. Curr Top Microbiol Immunol 270: 63–79
Atlan H, Cohen IR (1998) Immune information, self-organization and meaning. Int Immunol 10: 711–717
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Basel AG
About this chapter
Cite this chapter
Cohen, I.R., Quintana, F.J., Nussbaum, G., Cohen, M., ZaninZhorov, A., Lider, O. (2003). HSP60 and the regulation of inflammation: Physiological and pathological. In: van Eden, W. (eds) Heat Shock Proteins and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8028-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8028-2_1
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9410-4
Online ISBN: 978-3-0348-8028-2
eBook Packages: Springer Book Archive