Skip to main content
SpringerLink
Log in

Potential of p38 MAP kinase inhibitors in the treatment of cancer

  • Chapter
Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 60))

Summary

The involvement of chronic inflammation in tumor development and progression is reviewed. Based on the natural history of certain diseases and epidemiology studies, a strong association has been established between particular chronic inflammatory conditions and eventual tumor appearance. Solid tumors require a stroma for their growth and recruit macrophages to synthesize essential growth and angiogenic factors that they do not have the capacity to produce. The microenvironment of the local host tissue appears to be an active participant in exchanging cytokines and enzymes with tumor cells that modify the local extracellular matrix, stimulate migration, and promote tumor angiogenesis, proliferation and survival. The role of p38 MAP kinase as a therapeutic target for treating cancer is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Abbreviations

MAP:

mitogen-activated protein

TNF-α:

tumor necrosis factor-α

MMP:

matrix metalloproteinase

FGF:

fibroblast growth factor

TGF-β:

transforming growth factor-β

EGF:

epidermal growth factor

TPA:

12-O-tetradecanoylphorbol-13-acetate

IL-1:

interleukin-1

MCP-1:

monocyte chemoattractant protein-1

VEGF:

vascular endothelial growth factor

ICAM-1:

intercellular adhesion molecule-1

CHO:

Chinese hamster ovary

NSAID:

nonsteroidal anti-infammatory drug

MK2 or MAPKAP kinase 2:

MAP kinase-activated protein kinase 2

References

  1. F. Balkwill and A. Mantovani: Lancet 357, 539 (2001)

    PubMed  CAS  Google Scholar 

  2. R. Virchow, in: A. Hirschwald (ed.): Dreissig Vorlesungen gehalten während des Win-tersemesters 1862–1863 an der Universität zu Berlin. Vorlesungen über Pathologie 3, 2, Berlin (1863)

    Google Scholar 

  3. T. Tanaka, H. Kohno, M. Murakami, R. Shimada and S. Kagami: Oncol. Rep. 7, 501 (2000)

    CAS  Google Scholar 

  4. R.J.H. Collins, M. Feldman and J.S. Fordtran: N. Engl. J. Med.316 1654 (1987)

    PubMed  Google Scholar 

  5. B.I. Korelitz: Am. J. Gastroenterol.78 44 (1983)

    PubMed  CAS  Google Scholar 

  6. M. Chen and K. Mott: Trop. Dis. Bull.85 2056 (1988)

    Google Scholar 

  7. A.J. Cameron, B.J. Ott and W.S. Payne: N. Engl. J. Med.313 857 (1985)

    PubMed  CAS  Google Scholar 

  8. B.B. Dahms and F.C. Rothstein:Gastroenterology 86, 318 (1984)

    PubMed  CAS  Google Scholar 

  9. A.B. Lowenfels, P. Maisonneuve and G. Cavallini: N. Engl. J. Med.313 857 (1985)

    Google Scholar 

  10. A.K. Diehl: JAMA250 2323 (1983)

    PubMed  CAS  Google Scholar 

  11. M.J. Blaser: Gastroenterology102 1720 (1992)

    Google Scholar 

  12. P. Correa: Cancer Res.48 3554 (1988)

    PubMed  CAS  Google Scholar 

  13. M. Chen and K. Mott: Trop. Dis. Bull.86 2 (1989)

    Google Scholar 

  14. J.R. Locke, D.E. Hill and Y. Walzer: J. Urol.133 1034 (1985)

    PubMed  CAS  Google Scholar 

  15. J.G. Edwards, K.R. Abrams, J.N. Leverment, T.J. Spyt, D.A. Waller and K.J. O’Byrne: Tho-rax55 731 (2000)

    CAS  Google Scholar 

  16. E. Tabor and K. Kobayashi: J. Natl. Cancer Inst.84 86 (1992)

    PubMed  CAS  Google Scholar 

  17. F.-S. Yeh, M. C. Yu, C.-C. Mo, S. Luo, M. J. Tong and B. E. Henderson: Cancer Res. 49, 2506 (1989)

    PubMed  CAS  Google Scholar 

  18. International Agency for Research on Cancer: Schistosomes, liver flukes and Helicobac-ter pylori, IARC Monograph, International Agency for Research on Cancer, Lyon, France 1994

    Google Scholar 

  19. D.R. Lowy, R. Kirnbauer and J.T. Schiller: Proc. Natl. Acad. Sci. USA91 2436 (1994)

    PubMed  CAS  Google Scholar 

  20. M.H. Schiffman: J. Natl. Cancer Inst.84 394 (1992)

    Google Scholar 

  21. H.A. Risch and G.R. Howe: Cancer Epidemiol Biomarkers and Prevention 4 447 (1995)

    CAS  Google Scholar 

  22. D.H. Wright: J. Pathol.177 331 (1995)

    PubMed  CAS  Google Scholar 

  23. A.H. Crickshank, E.M. McConnell and D.G. Miller: J. Clin. Pathol.16 573 (1963)

    Google Scholar 

  24. V. Menkin: Br. Med. J.5186 1585 (1960)

    Google Scholar 

  25. D. Whitby and C. Boshoff: Curr. Opin. Oncol.10 405 (1998)

    PubMed  CAS  Google Scholar 

  26. N. Kitagawa, M. Goto, K. Kurozumi, S. Maruo, M. Fukayama, T. Naoe, M. Yasukawa, K. Hino, T. Suzuki, S. Todo et al.: EMBO J.19 6742 (2000)

    PubMed  CAS  Google Scholar 

  27. M.Y. Liu, Y.Y. Shih, L.Y. Li, S.P. Chou, T.S. Sheen, C.L. Chen, C.S. Yang and J.Y. Chen: J. Med. Virol.61 241 (2000)

    PubMed  CAS  Google Scholar 

  28. S.T. Mayne, J. Buenconsejo and D.T. Janerich: Am. J. Epidemiol.149 13 (1999)

    PubMed  CAS  Google Scholar 

  29. S.O.P. Hofer, G. Molema, R.A.E.C. Hermens, H.J. Wanebo, J.S. Reichner and H.J. Hoek-stra: Europ. J. Surg. Oncol.25 231 (1999)

    CAS  Google Scholar 

  30. S.A. Weitzman and L.I. Gordon:Blood 76,655 (1990)

    PubMed  CAS  Google Scholar 

  31. D.S. Dolberg, R. Hollingsworth, M. Hertle and M.J. Bissell: Science230 676 (1985)

    PubMed  CAS  Google Scholar 

  32. M.H. Sieweke, A.W. Stoker and M.J. Bissell: Cancer Res. 49, 2419 (1989)

    Google Scholar 

  33. M.H. Sieweke, N.L. Thompson, M.B. Sporn and M.J. Bissell: Science248 1656 (1990)

    PubMed  CAS  Google Scholar 

  34. M.A. Wainberg, B. Beiss, H. Fong, S. Beaupre and J. Menezes: Cancer Res.43 1550 (1983)

    Google Scholar 

  35. A. Konstantinides, J.B. Smulow and C. Sonnenschein: Science 216 1235 (1982)

    Google Scholar 

  36. M.P. Waalkes, S. Rehm, K.S. Kasprzak and H J. Issaq: Cancer Res. 47, 2445 (1987)

    PubMed  CAS  Google Scholar 

  37. J.F. Chester, H.A. Gaissert, J.S. Ross, R.A. Malt and S.A. Weitzman: Br. J. Cancer59 704 (1989)

    PubMed  CAS  Google Scholar 

  38. K.M. Pozharisski: Cancer Res. 35, 3824 (1975)

    PubMed  CAS  Google Scholar 

  39. C.P. Davis, M.S. Cohen, M.B. Gruber, M.D. Anderson and M.M. Warren: J. Urol.132 1025 (1984)

    PubMed  CAS  Google Scholar 

  40. J.F. Chester, H. Gaissert, J.S. Ross, R.A. Malt and S.A Weitzman: J. Urol.137 769 (1987)

    PubMed  CAS  Google Scholar 

  41. T.S. Argyris and T.J. Slaga: Cancer Res.41 5793 (1981)

    Google Scholar 

  42. B.D. Pullinger: J. Pathol. 57, 477 (1945)

    CAS  Google Scholar 

  43. I. McKenzie and P. Rous: J. Exp. Med. 73, 391 (1941)

    Google Scholar 

  44. A.C. Shuh, S.J. Keating, F.S. Monteclaro, P.K. Vogt and M.L. Breitman: X Nature346 756 (1990)

    Google Scholar 

  45. M. Nerenberg, S.H. Hinrichs, R.K. Reynolds, G. Khoury and G. Jay: Science237 1324 (1987)

    PubMed  CAS  Google Scholar 

  46. B. Vogelstein, E.R. Fearon, S.R. Hamilton, S.E. Kern, A.C. Preisinger, M. Leppert, Y. Naka-mura, R. White, A.M. Smits and J.L. Bos: N. Engl. J. Med.319 525 (1988)

    PubMed  CAS  Google Scholar 

  47. C. Lengauer, K.W. Kinzler and B. Vogelstein: Nature396 643 (1998)

    PubMed  CAS  Google Scholar 

  48. A. Raza: Leuk. Res.24 63 (2000)

    PubMed  CAS  Google Scholar 

  49. T.J. Slage, S.M. Fischer, C.E1. Weeks and A.J.P. Klein-Szanto, in: M. Seije and I.A. Bern-stein (eds): Biochemistry of normal and abnormal epidermal differentiation, University of Tokyo Press, Tokyo 1980, 19–38

    Google Scholar 

  50. I. Clark-Lewis and A. Murray: Cancer Res.38 494 (1978)

    PubMed  CAS  Google Scholar 

  51. A.N. Raick: Cancer Res.34 920 (1974)

    PubMed  CAS  Google Scholar 

  52. T.L. Slaga, S.M. Fiscer, A. Viaje, D.L. Berry, W.M. Bracken, S. LeClerc and D.R. Miller, in: T.J. Slaga, A. Sivak and R.K. Boutwell (eds): Carcinogenesis, Vol.2. Mechanisms of tumor promotion and carcinogenesis, Raven Press, New York 1978, 173–195

    Google Scholar 

  53. R.M. Schultz, M.A. Chingos and Z.L. Olkowski: Cell Immunol.54 98 (1980)

    PubMed  CAS  Google Scholar 

  54. S.M. Fischer and J. DiGiovanni: Cancer Bull. 47, 456 (1995)

    Google Scholar 

  55. J. DiGiovanni: Pharmacol. Ther. 54, 63 (1992)

    PubMed  CAS  Google Scholar 

  56. S.D. Hursting, T.J. Slaga, S.M. Fischer, J. DiGiovanni and J.M. Phang: J. Natl. Cancer Inst.91, 215 (1999)

    PubMed  CAS  Google Scholar 

  57. K.J. O’Byrne and A.G. Dalgleish: Br. J. Cancer85, 473 (2001)

    PubMed  Google Scholar 

  58. H. Oshima and H. Bartsch: Mutation Res.305 253 (1994)

    Google Scholar 

  59. H. Fujiki and M. Suganuma: J Cancer Res. Clin. Oncol.125 150 (1999)

    PubMed  CAS  Google Scholar 

  60. A. Komori, J. Yatsunami, M. Suganuma, S. Okabe, S. Abe, A. Sakai, K. Sasaki and H. Fujiki: Cancer Res. 53, 1982 (1993)

    PubMed  CAS  Google Scholar 

  61. R.J. Moore, D.M. Owens, G. Stamp, C. Arnott, E. Burke, N. East, H. Holdsworth, L. Turner, B. Rollins, M. Pasparakin et al.: Nature Med. 5, 828 (1999)

    PubMed  CAS  Google Scholar 

  62. M.L. Harris, H.J. Schiller, P.M. Reilly, M. Donowitz, M.B. Grisham and G.B. Bulkley: Phar-macol. Ther.53 375 (1992)

    CAS  Google Scholar 

  63. T.W. Kensler, M.A. Trush and K.Z. Guyton, in: V.E. Steel, G.D. Stoner, C.W. Boone and G.J. Kelloff (eds.): Cellular and molecular targets for chemoprevention, CRC Press, Ann Arbor 1992, 173–191

    Google Scholar 

  64. J. O’Brien: Free Radical Biol. Med.4 216 (1988)

    Google Scholar 

  65. M.A. Marietta: Chem. Res. Toxicol.1 249 (1988)

    Google Scholar 

  66. G. Tremblay: Exp. Mol. Pathol.31 248 (1979)

    PubMed  CAS  Google Scholar 

  67. R. Seljelid, S. Jozefowski and B. Sveinbjornsson: AntiCancer Res.19 4809 (1999)

    PubMed  CAS  Google Scholar 

  68. J. Folkman: Adv. Cancer Res.43 175 (1985)

    PubMed  CAS  Google Scholar 

  69. H.F. Dvorak: New Engl. J. Med.315 1650 (1986)

    PubMed  CAS  Google Scholar 

  70. L. Morgenstern, T. Yamakawa and D. Seltzer: Am. J. Surg.125 29 (1973)

    PubMed  CAS  Google Scholar 

  71. S.E. Miederer, R. Muller, K. Kutz, E. Wobser and K. Elster: Endoscopy9 50 (1977)

    Google Scholar 

  72. A. Breen and R. Bleday: Surg. Clin. North Am.77 17 (1997)

    Google Scholar 

  73. J. Folkman: An. N.Y. Acad. Sci.401 212 (1982)

    CAS  Google Scholar 

  74. J. Folkman: Nature Med.1 27 (1995)

    PubMed  CAS  Google Scholar 

  75. W. Auerbach and R. Auerbach: Pharmacol. Ther. 63, 265 (1994)

    PubMed  CAS  Google Scholar 

  76. J.R. Jackson, M.P. Seed, C.H. Kircher, D.A. Willoughby and J.D. Winkler: FASEB J.11 457 (1997)

    PubMed  CAS  Google Scholar 

  77. A.E. Koch, P.J. Polverini and J.L. Leibovich: J. Leuk. Biol.39 233 (1986)

    CAS  Google Scholar 

  78. C. Sunderkotter, K. Steinbrink, M. Goebeler, R. Bhardwaj and C. Sorg: J. Leuk. Biol. 55, 410 (1994)

    CAS  Google Scholar 

  79. P.J. Polverini and S.J. Leibovich: Lab. Invest.51 635 (1984)

    PubMed  CAS  Google Scholar 

  80. R. Evans: Br. J. Cancer37 1086 (1978)

    PubMed  CAS  Google Scholar 

  81. R. Evans: Int. J. Cancer20 120 (1977)

    PubMed  CAS  Google Scholar 

  82. R. Evans and L.G. Eidlen, in: S. Normann and E. Sorkin (eds.): Macrophages and natural killer cells: regulation and function, Plenum Publishing Co, New York 1982, 379–387

    Google Scholar 

  83. S.A. Kadhim and R.C. Rees: Cell Immunol.87 259 (1984)

    PubMed  CAS  Google Scholar 

  84. L.K. Mostafa, D.B. Jones and D.H. Wright: J. Pathol.132 191 (1980)

    PubMed  CAS  Google Scholar 

  85. W. Stenzinger, J. Bruggen, E. Macher and C. Sorg: Eur. J. Cancer. Clin. Oncol. 191,49 (1983)

    Google Scholar 

  86. G. Richter, S. Kruger-Krasagakes, G. Hein, C. Huls, E. Schmitt, T. Diamantstein and T. Blankenstein: Cancer Res. 53, 4134 (1993)

    PubMed  CAS  Google Scholar 

  87. D.R. Knighton, T.K. Hunt, H. Scheuenstuhl, B.J. Halliday, Z. Werb and M.J. Banda: Sci-ence221 1283 (1983)

    CAS  Google Scholar 

  88. P. J. Polverini: Eur. J. Cancer32A 2430 (1996)

    PubMed  CAS  Google Scholar 

  89. Z. Dong, G. Greene, C. Pettaway, C.P.N. Dinney, I. Eue, W. Lu, C.D. Bucana, M. Balbay, D. Bielenberg and I.J. Fidler: Cancer Res.59 872 (1999)

    CAS  Google Scholar 

  90. C.E. Lewis, R. Leek, A. Harris and J.O’D. McGee: J. Leuk. Biol. 57, 747 (1995)

    CAS  Google Scholar 

  91. R.D. Leek, C.E. Lewis, R. Whitehouse, M. Greenall, J. Clarke and A.L. Harris: Cancer Res.56 4625 (1996)

    PubMed  CAS  Google Scholar 

  92. M. Matsumura, Y. Chiba, C. Lu, H. Amaya, T. Shimomatsuya, T. Horiuchi, R. Muraoka and N. Tanigawa: Cancer Lett.128 55 (1998)

    PubMed  CAS  Google Scholar 

  93. I. Takanami, K. Takeuchi and S. Kodaira: Oncology 57, 138 (1999)

    PubMed  CAS  Google Scholar 

  94. M. Ono, H. Torisu, J. Fukushi, A. Nishie and M. Kuwano: Cancer Chemother. Pharma-col.43 (Suppl), S69 (1999)

    CAS  Google Scholar 

  95. T. Etoh, K. Shibuta, G.F. Barnard, S. Kitano and I. Mori: Clin. Cancer Res.6 3545 (2000)

    PubMed  CAS  Google Scholar 

  96. L. Zhang, A. Khayat, H. Cheng and D.T. Graves: Lab. Invest.76 579 (1997)

    PubMed  CAS  Google Scholar 

  97. V. Goede, L. Brogelli, M. Ziche and H.G. Augustin: Int. J. Cancer82,765 (1999)

    PubMed  CAS  Google Scholar 

  98. I.B. Joseph and J.T. Issacs: J. Natl. Cancer Inst.90 1648 (1998)

    PubMed  CAS  Google Scholar 

  99. S.J. Leibovich, P.J. Polverini, H.M. Shepard, D.M. Wiseman, V. Shively and N. Nuseir: Nature329 630 (1987)

    PubMed  CAS  Google Scholar 

  100. S Yoshida, M. Ono, T. Shono, H. Izumi, T. Ishibashi, H. Suzuki and M. Kuwano: Molec. Cellular Biol.17 4015 (1997)

    CAS  Google Scholar 

  101. N. Gupta, N. Khodarev, J. Yu and R. P. Weichselbaum: Proc. Am. Assoc. Cancer Res.41 480[A3063] (2000)

    Google Scholar 

  102. M. Ryuto, M. Ono, H. Izumi, S. Yoshida, H. A. Weich, K. Kohno and M. Kuwano: J. Biol. Chem.271 28220 (1996)

    PubMed  CAS  Google Scholar 

  103. J.C. Lee, J.T. Layton, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys, W. Landvatter et al.: Nature372 739 (1994)

    PubMed  CAS  Google Scholar 

  104. M. Goebeler, K. Kilian, R. Gillitzer, M. Kunz, T. Yoshimura, E. Brocker, U. Rapp and S. Ludwig: Blood 93, 857 (1999)

    PubMed  CAS  Google Scholar 

  105. S. Rousseau, F. Houle, J. Landry and J. Huot: Oncogene15 2169 (1997)

    PubMed  CAS  Google Scholar 

  106. J.C. Lee, S. Kassis, S. Kumar, A. Badger and J.L. Adams: Pharmacol. Ther.82 389 (1999)

    PubMed  CAS  Google Scholar 

  107. J.M. Ayala, S. Goyal, N.J. Liverton, D.A. Claremon, S.J. O’Keefe and W.A. Hanlon: J. Leuk. Biol.67, 869 (2000)

    CAS  Google Scholar 

  108. K. Tanaka, M. Abe and Y. Sato: Jpn. J. Cancer Res.90 647 (1999)

    PubMed  CAS  Google Scholar 

  109. J.R. Jackson, B. Bolognese, L. Hillegass, S. Kassis, J. Adams, D.E. Griswold and J.D. Win-kler: J. Pharmacol. Exp. Ther.284 687 (1998)

    PubMed  CAS  Google Scholar 

  110. J.S. Mudgett, J. Ding, L. Guh-Siesel, N.A. Chartrain, L. Yang, M.S. Gopal and M.M. Shen: Proc. Natl. Acad. Sci. USA97 10454 (2000)

    PubMed  CAS  Google Scholar 

  111. P. Orosz, B. Echtenacher, W. Falk, J. Ruschoff, D. Weber and D.N. Mannel: J. Exp. Med.177 1391 (1993)

    PubMed  CAS  Google Scholar 

  112. P. Orosz, A. Kruger, M. Hubbe, J. Ruschoff, P.V. Hoegen and D.N. Mannel: Int. J. Cancer60 867 (1995)

    PubMed  CAS  Google Scholar 

  113. T. Blankenstein: Folia Biologica (Praha)40 19 (1994)

    PubMed  CAS  Google Scholar 

  114. Z. Qin, S. Kruger-Krasagakes, U. Kunzendorf, H. Hock, T. Diamantstein and T. Blanken-stein: J. Exp. Med.178 355 (1993)

    PubMed  CAS  Google Scholar 

  115. S.T.A. Malik, M.S. Naylor, N. East, A. Oliff and F.R. Balkwill: Eur. J. Cancer26, 1031 (1990)

    PubMed  CAS  Google Scholar 

  116. W. Wu, T. Yamaura, K. Murakami, M. Ogasawara, K. Hayashi, J. Murata and I. Saiki: Oncol. Res.11 461 (1999)

    PubMed  CAS  Google Scholar 

  117. M.R. Bani, A. Garofalo, E. Scanziani and R. Giavazzi: J. Natl. Cancer Inst. 83, 119 (1991)

    CAS  Google Scholar 

  118. R. Giavazzi, A. Garofalo, M.R. Bani, M. Abbate, P. Ghezzi, D. Boraschi, A. Mantovani and E. Dejana: Cancer Res.50 4771 (1990)

    CAS  Google Scholar 

  119. F. Vidal-Vanaclocha, C. Amezaga, A. Asumendi, G. Kaplanski and C.A. Dinarello: Can-cer Res.54 2667 (1994)

    CAS  Google Scholar 

  120. G. Dong, Z. Chen, T. Kato and C. Van Waes: Cancer Res. 59, 3495 (1999)

    PubMed  CAS  Google Scholar 

  121. J. Ocvirk, B. Stabuc, Z. Rudolf, V. Galvani and V. Curin-Serbec: Melanoma Res.10 253 (2000)

    CAS  Google Scholar 

  122. A. Ardizzoia, R. Lissoni, F. Brivio, E. Tisi, M. S. Perego, M.G. Grassi, S. Pittalis, S. Crispino, S. Barni and G. Tancini: J. Biol. Regul. Homeost. Agents6 103 (1992). Richard M. Schultz

    Google Scholar 

  123. J.H. Zhou and Y.G. Jiang: Chinese J. Oncol.16 132 (1994)

    CAS  Google Scholar 

  124. I.J. Fidler and G. Poste: Hospital practice (office edition) 1757 (1982)

    Google Scholar 

  125. D.L. Aukerman, J.E. Price and 1J. Fidler: J. Nat. Cancer Inst. 77, 915 (1986)

    PubMed  CAS  Google Scholar 

  126. I.J. Fidler: Cancer J.6 (suppl. 2), S134 (2000)

    PubMed  Google Scholar 

  127. K. Harimaya, K. Tanaka, Y. Matsumoto, H. Sato, S. Matsuda and Y. Iwamoto: Clin. Exp. Metastasis 18, 121 (2000)

    PubMed  CAS  Google Scholar 

  128. A. Kawashima, I. Nakanishi, H. Tsuchiya, A. Roessner, K. Obata and Y. Okada: Virchows Archiv 424,547 (1994)

    PubMed  CAS  Google Scholar 

  129. A. Waterston, F. Salway, C. Smith, E. Andreakos, S. Mouritsen, M. Feldmann and C. Coombes: Proc. Am. Assoc. Cancer. Res.43 8 (2002)

    Google Scholar 

  130. D.N. Mannel, P. Grosz, M. Hafner and W. Falk: Circulatory Shock 44,9 (1994)

    PubMed  CAS  Google Scholar 

  131. B. Stoelcker, M. Hafner, P. Grosz, B. Nieswandt and D.N. Mannel: J. Inflammation46 155 (1996)

    CAS  Google Scholar 

  132. M. E. Miele, C. F. Bennett, B. E. Miller and D. R. Welch: Exp Cell Res 214, 231 (1994)

    PubMed  CAS  Google Scholar 

  133. F. Vidal-Vanaclocha, G. Fantuzzi, L. Mendoza, A.M. Fuentes, M.J. Anasagasti, J. Martin, T. Carrascal, P. Walsh, L.L. Reznikov, S.H. Kim et al.: Proc. Natl. Acad. Sci. USA97 734 (2000)

    PubMed  CAS  Google Scholar 

  134. K. Miyata, Y. Mitsuishi, H. Shikama, K. Kuroda, K. Nishimura, N. Sakae and M. Kato: J. Interferon Cytokine Res.15 161 (1995)

    CAS  Google Scholar 

  135. M. Bereta, J. Bereta, S. Cohen, K. Zaifert and M.C. Cohen: Cell Immunol. 136, 263 (1991)

    PubMed  CAS  Google Scholar 

  136. M. Frater-Schroeder, W. Risau, R. Hallman, P. Gautschi and P. Bohlen: Proc. Natl. Acad. Sci. USA84 5277 (1987)

    CAS  Google Scholar 

  137. E.M. Rosen, I.D. Goldberg, D. Liu, E. Setter, M.A. Donavan, M. Bhargava, M. Reiss and B.M. Kacinski: Cancer Res. 51, 5315 (1991)

    PubMed  CAS  Google Scholar 

  138. M. Hafner, P. Grosz, A. Kruger and D.N. Mannel: Int. J. Cancer66, 388 (1996)

    PubMed  CAS  Google Scholar 

  139. D.R. Bertolini, G.E. Nedwin, T.S. Bringman, D.D. Smith and G.R. Mundy: Nature319 516 (1986)

    CAS  Google Scholar 

  140. F.R. Balkwill: Progress in Growth Factor Res. 4, 121 (1992)

    CAS  Google Scholar 

  141. L.A. Liotta: Cancer Res.46 1 (1986)

    PubMed  CAS  Google Scholar 

  142. A. Pietersma, B.C. Tilly, M. Gaestel, N. de Jong, J.C. Lee, J.F. Koster and W. Sluiter: Bio-chem. Biophys. Res. Commun.230 44 (1997)

    CAS  Google Scholar 

  143. E. Paine, R. Palmantier, S.K. Akiyama, K. Olden and J.D. Roberts: J. Biol. Chem.275 11284 (2000)

    PubMed  CAS  Google Scholar 

  144. S. Hayes and R. Bergan: Proc. Am. Assoc. Cancer Res.43 22 (2002)

    Google Scholar 

  145. J. Laferriere, F. Houle, M.M. Taher, K. Valerie and J. Huot: J. Biol. Chem.276 33762 (2001)

    PubMed  CAS  Google Scholar 

  146. P.A. Andreasen, L. Knoller, L. Christensen and M.J. Duffy: Int. J. Cancer72 1 (1997)

    PubMed  CAS  Google Scholar 

  147. G. Opdenakker and J.V. Damme: Cytokine 4, 251 (1992)

    PubMed  CAS  Google Scholar 

  148. D. Mullins and S.T. Rohrlich: Biochim. Biophys. Acta695 177 (1983)

    PubMed  CAS  Google Scholar 

  149. J. Westermark and V.M. Kahari: FASEB J. 13, 781 (1999)

    Google Scholar 

  150. J. Chen, C. Baskerville, Q. Han, Z.K. Pan and S. Huang: J. Biol. Chem.276 47901 (2001)

    PubMed  CAS  Google Scholar 

  151. S. Huang, L. New, Z. Pan, J. Han and G.R. Nemerow: J. Biol. Chem.275 12266 (2000)

    PubMed  CAS  Google Scholar 

  152. N. Reunanen, J. Han, M. Foschi and V. Kahari: Proc. Am. Assoc. Cancer Res.43 7 (2002)

    Google Scholar 

  153. C. Simon, M. Simon, G. Vucelic, M.J. Hicks, P.K. Plinkert, A. Koitschev and H.P. Zenner: Exp. Cell Res.271 344 (2001)

    PubMed  CAS  Google Scholar 

  154. C. Denkert, A. Siegert, A. Leclere, A. Turzynski and S. Hauptmann: Clin. Exp. Metastasis 19, 79 (2002)

    PubMed  CAS  Google Scholar 

  155. Y.D. Jung, B.A. Shin, H.R. Kim, B.W. Ahn, C.K. Cho and L.M. Ellis: Proc. Am. Assoc. Can-cer Res. 439 (2002)

    Google Scholar 

  156. S. Huang: J. Natl. Cancer Inst.94 1134 (2002)

    PubMed  CAS  Google Scholar 

  157. M.S. Naylor and F.R. Balkwill: Cell Proliferation Cancer 105,107 (1996)

    Google Scholar 

  158. S. Akiro and T. Kishimoto: Sem. Cancer Biol. 3, 17 (1992)

    Google Scholar 

  159. M. Kawano, T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H.Asaoku, B. Tang, O. Tan-abe, H. Tanaka, A. Kuramoto and T. Kishimoto: Nature332 83 (1988)

    CAS  Google Scholar 

  160. B. Klein, X.-G. Zhang, M. Jourdan, J. Content, M. Aarden, M. Piechaczyk and R. Bataille:Blood 73, 517 (1989)

    PubMed  CAS  Google Scholar 

  161. G. Schwab, C.B. Siegall, L.A. Aarden, L.M. Neckers and R.P. Nordan: Blood 77, 587 (1991)

    PubMed  CAS  Google Scholar 

  162. G. Scala, I. Quinto, M.R. Ruocco, A. Arcucci, M. Mallardo, P. Caretto, G. Forni and S. Venuta: J. Exp. Med.172 61 (1990)

    PubMed  CAS  Google Scholar 

  163. C. Yee, A. Biondi, X.H. Wang, N.N. Iscove, J. de Sousa, L.A. Aarden, G.G. Wong, S.C. Clark, H.A. Messner and M.D. Minden:Blood74,798 (1989)

    PubMed  CAS  Google Scholar 

  164. A. Bioni, V. Rossi, R. Bassan, T. Barbui, S. Bettoni, M. Sironi, A. Mantovani and A. Ram-baldi: Blood 73, 1279 (1989)

    Google Scholar 

  165. W. Oster, N.A. Cicco, H. Klein, T. Hirano, T. Kishimoto, A. Lindenmann, R.H. Mertels-mann and F. Herrmann: J. Clin. Invest.84 451 (1989)

    PubMed  CAS  Google Scholar 

  166. R. Kurzrock: Clin. Cancer Res. 3, 2581 (1997)

    PubMed  CAS  Google Scholar 

  167. L.J. Old: Science230 630 (1985)

    PubMed  CAS  Google Scholar 

  168. R.Y. Liu, C. Fan, S. Mitchell, Q. Chen, J. Wu and K.S. Zuckerman: Cancer Res.58 2217 (1998)

    PubMed  CAS  Google Scholar 

  169. H.G. Drexler, M. Zaborski and H. Quentmeier: Leukemia (Baltimore) 11, 541 (1997)

    CAS  Google Scholar 

  170. R.Y. Liu, C. Fan, N.E. Olashaw, X. Wang and K.S. Zuckerman: J. Biol. Chem. 274, 13877 (1999)

    PubMed  CAS  Google Scholar 

  171. R.Y. Liu, C. Fan, G. Liu, N.E. Olashaw and K.S. Zuckerman: J. Biol. Chem.275 21086 (2000)

    CAS  Google Scholar 

  172. A. Carter, S. Merchav, I. Silvian-Draxler and I. Tatarsky: Br. J. Haematol.74 424 (1990)

    PubMed  CAS  Google Scholar 

  173. F. Kallinowski, C. Schaefer, G. Tyler and P. Vaupel: Br. J. Cancer60 555 (1989)

    PubMed  CAS  Google Scholar 

  174. J. Gelin, L.L. Moldawer, C. Lonroth, B. Sherry, R. Chizzonite and K. Lundholm: Cancer Res. 51,415 (1991)

    PubMed  CAS  Google Scholar 

  175. G. Salles, J. Bienvenu and Y. Bastion: Br. J. Haematol.93 352 (1996)

    PubMed  CAS  Google Scholar 

  176. K. Warzocha, G. Salles, J. Bienvenu, Y. Bastion, C. Dumontet, N. Renard, E.-M. Neidhardt-Berard and B. Coiffier: J. Clin. Oncol.15 499 (1997)

    PubMed  CAS  Google Scholar 

  177. K. Sakamoto, T. Masuda, S. Mita, T. Ishiko, Y. Nakashima, H. Arakawa, H. Egami, S. Harada, K. Matsushima and M. Ogawa: Int. J. Clin. Lab. Res.22 216 (1992)

    PubMed  CAS  Google Scholar 

  178. K. Xie: Cytokine Growth Factor Rev.12 375 (2001)

    PubMed  CAS  Google Scholar 

  179. D. Schadendorf, A. Moller, B. Algermissen, M. Worm, M. Sticherling and B.M. Czarnet-zki: J. Immunol.151 2667 (1993)

    PubMed  CAS  Google Scholar 

  180. G. Krueger, C. Jorgenson, C. Miller, J. Schroeder, M. Sticherling and E. Christopher: J. Invest. Dermatol.94 545 (1990)

    Google Scholar 

  181. R.K. Singh, M. Gutman, R. Radinsky, C.D. Bucana and I.J. Fidler: Cancer Res.54 3242 (1994)

    CAS  Google Scholar 

  182. M. Gutman, R.K. Singh, K. Xie, C.D. Bucana and I.J. Fidler: Cancer Res. 55, 2470 (1995)

    CAS  Google Scholar 

  183. R. Brew, J.S. Erikson, D.C. West, B.F. Flanagan and S.E. Christmas: Biochem. Soc. Trans.25 264S (1997). Richard M. Schultz

    PubMed  CAS  Google Scholar 

  184. R. Brew, J.S. Erikson, D.C. West, A.R. Kinsella, J. Slavin and S.E. Christmas: Cytokine 12, 78 (2000)

    PubMed  CAS  Google Scholar 

  185. M. Miyamoto, Y. Skimizu, K. Okada, Y. Kashii, K. Higuchi and A. Watanabe: Cancer Immunol. Immunother. 47, 47 (1998)

    PubMed  CAS  Google Scholar 

  186. G. Galffy, K.A. Mohammed, P.A. Dowling, N. Nasreen, M.J. Ward and V.B. Antony: Can-cer Res.59 367 (1999)

    CAS  Google Scholar 

  187. Y. Noguchi, T. Yoshikawa, A. Matsumoto, G. Svaninger and J. Gelin: Surg. Today26 467 (1996)

    PubMed  CAS  Google Scholar 

  188. M. Kawakami and A. Cerami: J. Exp. Med.154 631 (1981)

    PubMed  CAS  Google Scholar 

  189. B. Beutler, I.W. Milsark and A.C. Cerami: Nature319 516 (1985)

    Google Scholar 

  190. G. Darling, D.L. Raker, J.J. Christian, C.M. Gorschboth and J.A. Norton: Cancer Res.50 4008 (1990)

    CAS  Google Scholar 

  191. A. Oliff, D. Defeo-Jones, M. Boyer, D. Martinez, D. Kiefer, G. Voucolo, A. Wolfe and S.H. Socher: Cell 50, 555 (1987)

    PubMed  CAS  Google Scholar 

  192. R.A. Johnson, B.F. Boyce, G.R. Mundy and G.D. Roodman: Endocrinology124 1424 (1989)

    CAS  Google Scholar 

  193. D.H. Perlmutter, C.A. Dinarello, P.I. Punsal and H.R. Colten: J. Clin. Invest.78 1349 (1986)

    PubMed  CAS  Google Scholar 

  194. T. Yoneda, M.A. Alsina, J.B. Chavez, L. Bonewald, R. Nishimura and G.R. Mundy: J. Clin. Invest.87 977 (1991)

    PubMed  CAS  Google Scholar 

  195. K. Black, I.R. Garrett and G.R. Mundy: Endocrinol.128 2657 (1991)

    CAS  Google Scholar 

  196. A.S. Greenberg, R.P. Nordan, J. McIntosh, J.C. Calvo, R.D. Scow and D. Jablons: Cancer Res. 52, 4113 (1992)

    CAS  Google Scholar 

  197. L.L. Moldawer, M. Georgieff and K. Lundholm: Clin. Physiol. 7, 263 (1987)

    PubMed  CAS  Google Scholar 

  198. H.F. Starnes, R.S. Warren, M. Jeevanandam, J.L. Gabrilove, W. Larchian, H.F. Oettgen and M.F. Brennan: J. Clin. Invest.82 1321 (1988)

    PubMed  CAS  Google Scholar 

  199. P.A.J. Haslett: Sem. Oncol.25 (Suppl. 6), 53 (1998)

    CAS  Google Scholar 

  200. J.R. Henry, D.E. Cavender and S.A. Wadsworth: Drugs of the Future24 1345 (1999)

    CAS  Google Scholar 

  201. K. Ono and J. Han: Cell Signalling12 1 (2000)

    PubMed  CAS  Google Scholar 

  202. A. Greenberg, S. Basu, J. Hu, T. Yie, K.M. Tchou-Wong, W.N. Rom and T.C. Lee: Am. J. Respir. Cell Mol. Biol.26 558 (2002)

    PubMed  CAS  Google Scholar 

  203. B. Salh, A. Morotta, R. Wagey, M. Sayed and S. Pelech: Int. J. Cancer98 148 (2002)

    CAS  Google Scholar 

  204. S. Xiong, R. Grijalva, L. Zhang, N.T. Nguyen, P.W. Pisters, R.E. Pollock and D. Yu: Cancer Res. 61,1727 (2001)

    CAS  Google Scholar 

  205. H. Miki, H. Yamada and K. Mitamura: AntiCancer Res. 19, 5283 (1999)

    CAS  Google Scholar 

  206. S. Huang, L. New, Z. Pan, J. Han and G.R. Nemerow: J. Biol. Chem.275 12266 (2000)

    CAS  Google Scholar 

  207. R. Ben-Levy, S. Hooper, R. Wilson, H.F. Paterson and C.J. Marshall: Current Biol.8 1049 (1998)

    CAS  Google Scholar 

  208. A. Kotlyarov, A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H. D. Volk and M. Gaes-tel: Nature Cell Biol. 1, 94 (1999)

    PubMed  CAS  Google Scholar 

  209. R. DiMarco, J.E. Ensor and J.D. Hasday: Cell Immunol.140 304 (1992)

    Google Scholar 

  210. S.S. Bacus, A.V. Gudkov, M. Lowe, L. Lyass, Y. Yung, A.P. Komarov, K. Keyomarsi, Y. Yarden and R. Seger: Oncogene20, 147 (2001)

    CAS  Google Scholar 

  211. H. Karahashi, K. Nagata, K. Ishii and F. Amano: Biochim. Biophys. Acta1502 207 (2000)

    PubMed  CAS  Google Scholar 

  212. J. Varghese, S. Chattopadhaya and A. Sarin: J. Immunol.166 6570 (2001)

    PubMed  CAS  Google Scholar 

  213. A. Paul, A. Cuenda, C.E. Bryant, J. Murray, E.R. Chilvers, P. Cohen, G.W. Gould and R. Plevin: Cell Signal 11, 491 (1999)

    CAS  Google Scholar 

  214. X.M. Fan, B.C.Y. Wong, M.C.M. Lin, C.H. Cho, W.P. Wang, H.F. Fung and S.K. Lam.J Gastroenterol. Hepatol.16, 1098 (2001)

    CAS  Google Scholar 

  215. D.V. Bulavin, Y. Higashimoto, I.J. Popoff, W.A. Gaarde, V. Basrur, O. Potapova, E. Appella and A.J. Fornace: Nature411 102 (2001)

    PubMed  CAS  Google Scholar 

  216. C.A. Lange, J.K. Richer, T. Shen and K.B. Horwitz: J. Biol. Chem.273 31308 (1998)

    PubMed  CAS  Google Scholar 

  217. A. Paul, S. Wilson, C.M. Belham, C.J.M. Robinson, P.H. Scott, G.W. Gould and R. Plevin: Cell Signal 9, 403 (1997)

    CAS  Google Scholar 

  218. C.R. Couriel, K. Hicks, S. Giralt and R.E. Champlin: Curr. Opin. Oncol.12 582 (2000)

    PubMed  CAS  Google Scholar 

  219. M. Feldmann, J. Bondeson, F.M. Brennan, B.M.J. Foxwell and R.N. Maini: Annals Rheumatic Dis.58 (Suppl. 1), 27 (1999)

    Google Scholar 

  220. M. Potter: Adv. Exp. Med. Biol. 469, 151 (1999)

    PubMed  CAS  Google Scholar 

  221. A. Edbom, C. Helmick and M. Zack: N. Engl. J. Med.323 1228 (1990)

    Google Scholar 

  222. P.M. Choi and M.P. Zelig: Gut 35, 950 (1994)

    PubMed  CAS  Google Scholar 

  223. E. Shacter and S.A. Weitzman: Oncology 16,217 (2002)

    PubMed  Google Scholar 

  224. E. Fosslien: Annals Clin. Lab. Sci.30 3 (2000)

    CAS  Google Scholar 

  225. H. Coley-Nauts: Cancer Surveys8 713 (1989)

    Google Scholar 

  226. W.B. Coley: Am. J. Med. Sci.112 251 (1896)

    Google Scholar 

  227. E.A. Carswell, L.J. Old, R.J. Kassel, S. Green, N. Fiore and B. Williamson: Proc. Natl. Acad. Sci. USA72 3666 (1975)

    PubMed  CAS  Google Scholar 

  228. G.A. Granger and T.W. Williams: Nature 218, 403 (1968)

    Google Scholar 

  229. E.R. Feldman, E.T. Creagan, D.J. Schaid and D.L. Ahman: Am. J. Clin. Oncol.15 256 (1992)

    PubMed  CAS  Google Scholar 

  230. F.M. Muggia, T.D. Brown, P.J. Goodman, J.S. MacDonald, E.M. Hersh, T.R. Fleming and L. Leichman: Anticancer Drugs 3, 211 (1992)

    CAS  Google Scholar 

  231. F.J. Lejeune, C. Ruegg and D. Lienard: Curr. Opin. Immunol.10 573 (1998)

    PubMed  CAS  Google Scholar 

  232. M. Jaiswal, N.F. LaRusso, L.J. Burgart and G.J. Gores: Cancer Res. 60184 (2000)

    Google Scholar 

  233. D.R. Bertolini, G.E. Nedwin, R.S. Bringman, D.D. Smith and G.R. Mundy: Nature319 516 (1986)

    CAS  Google Scholar 

  234. T. Nacy, J. Janossy, C. Vizler, K. Bohus, F. Joo, P. Vegh and E. Duda: APMIS107 903 (1999)

    Google Scholar 

  235. M.P. Bevilacqua, J.S. Pober, M.E. Wheeler, R.S. Cotran and J.A. Gimborne: Proc. Natl. Acad. Sci. USA83 4533 (1985)

    Google Scholar 

  236. J. Vilcek, V.J. Palombella, D. Henriksen-DeStefano, C. Swenson, R. Feinman, M. Hirai and M. Tsujimoto: J. Exp. Med.163 632 (1986)

    PubMed  CAS  Google Scholar 

  237. A.E. Postlethwaite and J.M. Sayer: J. Exp. Med.172 1749 (1990)

    PubMed  CAS  Google Scholar 

  238. M.S. Naylor, G.W.H. Stamp, W.D. Foulkes, D. Eccles and F.R. Balkwill: J. Clin. Invest.91 2194 (1993)

    PubMed  CAS  Google Scholar 

  239. F.R. Balkwill: Progr. Growth Factor Res. 4, 121 (1992)

    CAS  Google Scholar 

  240. A. Mizokami, A. Gotoh, H. Yamada, E. T. Keller, C. Chang and T. Matsumoto: Proc. Am. Assoc. Cancer Res.40 64 (1999)

    Google Scholar 

  241. K. Warzocha, G. Salles, J. Bienvenu, Y. Bastion, C. Dumontet, N. Renard, E.M. Neidhardt-Berard and B. Coiffier: J. Clin. Oncol.15 499 (1997)

    PubMed  CAS  Google Scholar 

  242. R.C. Newton and C.P. Decicco: J. Med. Chem.42 2295 (1999)

    PubMed  CAS  Google Scholar 

  243. J.L. Adams, A.M. Badger, S. Kumar and J.C. Lee: Progr. Med. Chem.38 1 (2001)

    CAS  Google Scholar 

  244. N.J. Liverton, J.W. Butcher, C.F. Claiborne, D.A. Claremon, B.E. Libby, K.T. Nguyen, S.M. Pitzenberger, H.G. Selnick, G.R. Smith, A. Tebben et al.: J. Med. Chem. 42,2180 (1999). Richard M. Schultz

    CAS  Google Scholar 

  245. S.A. Wadsworth, D.E. Cavender, S.A. Beers, P. Lalan, P.H. Schafer, E.A. Malloy, W. Wu, B. Fahmy, G.C. Olini, J.E. Davis et al.: JPET291 680 (1999)

    CAS  Google Scholar 

  246. I.M. McLay, F. Halley, J.E. Souness, J. McKenna, V. Benning, M. Birrell, B. Burton, M. Belvisi, A. Collis, A. Constan et al.: Bioorg. Med. Chem.9 537 (2001)

    PubMed  CAS  Google Scholar 

  247. A. Wang, B.J. Canagarajah, J.C. Boehm, S. Kassisa, M.H. Cobb, R.P. Young, S. Abdel-Meguid, J.L. Adams and E.J. Goldsmith: Structure6 1117 (1998)

    PubMed  CAS  Google Scholar 

  248. F.G. Salituro, U.A. Germann, K.P. Wilson, G.W. Bemis, T. Fox and M.S. Su: Curr. Med. Chem.6 807 (1999)

    PubMed  CAS  Google Scholar 

  249. E. Herlaar and Z. Brown: Molec. Med. Today 5, 439 (1999)

    CAS  Google Scholar 

  250. P. LoGrasso, B. Fratz, A.M. Rolando, S.J. O’Keefe, J.D. Hermes and E.A. O’Neill: Biochem.36 10422 (1997)

    CAS  Google Scholar 

  251. P.R. Young, M.M. McLaughlin, S. Kuman, S. Kassis, M.L. Doyle, D. McNulty, T.F. Gal-lagher, S. Fisher, P.C. McDonnell, S.A. Carr et al.: J. Biol. Chem.272 12116 (1997)

    PubMed  CAS  Google Scholar 

  252. B. Frantz, T. Klatt, M. Pang, J. Parsons, A. Rolando, H. Williams, M.J. Tocci, S.J. O’Keefe and E.A. O’Neill: Biochem. 37–13 846 (1998)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cancer Research, Lilly Research Laboratories, Indianapolis, IN, 46285, USA

    Richard M. Schultz

Authors
  1. Richard M. Schultz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Basel AG

About this chapter

Cite this chapter

Schultz, R.M. (2003). Potential of p38 MAP kinase inhibitors in the treatment of cancer. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 60. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8012-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8012-1_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9402-9

  • Online ISBN: 978-3-0348-8012-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation