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Erectile dysfunction, depression, and pharmacological treatments: biologic interactions

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Sildenafil

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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Abstract

Sexual dysfunctions are common, in general, and especially prevalent among patients with psychiatric disorders. Male sexual dysfunction is associated with a range of imputed neurobiological, medical, psychological and interpersonal causes, and can have a significant impact on interpersonal functioning and quality of life. Moreover, the interaction between co-morbid sexual and psychiatric disorders has clinical implications for diagnosis, course, and treatment of both conditions. In recent years, there has been significant progress in the basic research and clinical therapeutics of male sexual dysfunction, with major advances in our understanding of the mechanisms of sexual response and the effects of pharmacologic agents on erectile function and orgasm. Here, we will briefly review the psychobiology of male sexual function and dysfunction, and describe diagnostic and therapeutic approaches; and then we will consider the interaction between erectile dysfunction and depression, with a focus on pharmacological treatments.

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References

  1. Seidman SN, Rieder RO (1994) A review of sexual behavior in the United States. Am J Psychiatry 151: 330–341

    CAS  PubMed  Google Scholar 

  2. Schiavi RC (1994) Effect of chronic disease and medication on sexual functioning. In: Rossi AS (ed): Sexuality across the life course. The University of Chicago Press, Chicago, 313–339

    Google Scholar 

  3. Meston CM, Frohlich PF (2000) The neurobiology of sexual function. Arch Gen Psychiatry 57: 1012–1030

    Article  CAS  PubMed  Google Scholar 

  4. Pfaus JG (1999) Neurobiology of sexual behavior. Curr Opin Neurobiol 9: 751–758

    Article  CAS  PubMed  Google Scholar 

  5. Rosen RC, Lane RM, Menza M (1999) Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 19: 67–85

    Article  CAS  PubMed  Google Scholar 

  6. Putnam SK, Du J, Sato S, Hull EM (2000) Testosterone restoration of copulatory behavior correlates with medial preoptic dopamine release in castrated male rats. Horm Behav 39: 216–224

    Article  Google Scholar 

  7. Rosen RC, Goldstein I (2003) Sexual Dysfunction. In: D. A. Warrell, T. M. Cox, J. D. Firth, E. J. Benz, Jr. (eds): Oxford Textbook of Medicine. Oxford University Press, Oxford

    Google Scholar 

  8. Masters WH, Johnson VE (1970) Human sexual inadequacy. Churchill Livingstone, Edinburgh

    Google Scholar 

  9. Schiavi RC, Mandeli J, Schreiner-Engel P, Chambers A (1991) Aging, sleep disorders, and male sexual function. Biol Psychiatry 30: 15–24

    Article  CAS  PubMed  Google Scholar 

  10. McKinlay JB, Longcope C, Gray A (1989) The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study. Maturitas 11: 103–115

    Article  CAS  PubMed  Google Scholar 

  11. Morales A, Heaton JP, Carson CC (2000) Andropause: a misnomer for a true clinical entity. J Urol 163: 705–712

    Article  CAS  PubMed  Google Scholar 

  12. Seidman SN, Walsh BT (1999) Testosterone and depression in aging men. Am J Geriatr Psychiatry 7: 18–33

    CAS  PubMed  Google Scholar 

  13. Segraves RT (1998) Definitions and classification of male sexual dysfunction. Int J Impot Res 10 Suppl 2: S54–S58

    Google Scholar 

  14. Schiavi RC, Segraves RT (1995) The biology of sexual function. Psychiatr Clin North Am 18: 7–23

    CAS  PubMed  Google Scholar 

  15. Simons JS, Carey MP (2001) Prevalence of sexual dysfunctions: results from a decade of research. Arch Sex Behav 30: 177–219

    Article  CAS  PubMed  Google Scholar 

  16. Laumann EO, Paik A, Rosen RC (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281: 537–544

    Article  CAS  PubMed  Google Scholar 

  17. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151: 54–61

    CAS  PubMed  Google Scholar 

  18. Araujo AB, Durante R, Feldman HA, Goldstein I, McKinlay JB (1998) The relationship between depressive symptoms and male erectile dysfunction: Cross sectional results from the Massachusetts Male Aging Study. Psychosom Med 60: 458–465

    CAS  PubMed  Google Scholar 

  19. Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC (2001) Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry 158: 1623–1630

    Article  CAS  PubMed  Google Scholar 

  20. Heiman JR (1998) Psychophysiological models of female sexual response. Int J Impot Res 10: S94–S97

    PubMed  Google Scholar 

  21. Burris AS, Banks SM, Carter CS, Davidson JM, Sherins RJ (1992) A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Andrology 13: 297–304

    CAS  Google Scholar 

  22. Schiavi RC, White D, Mandeli J, Levine AC (1997) Effect of testosterone administration on sex-ual behavior and mood in men with erectile dysfunction. Arch Sexual Behavior 26: 231–241

    Article  CAS  Google Scholar 

  23. St Lawrence JS, Madakasira S (1992) Evaluation and treatment of premature ejaculation: a critical review. Int J Psychiatry Med 22: 77–97

    Article  Google Scholar 

  24. Althof SE (1998) Evidence based assessment of rapid ejaculation. Int J Impot Res 10 (Suppl 2): S74–S76

    Article  PubMed  Google Scholar 

  25. Colpi GM, Fanciullacci F, Beretta G, Negri L, Zanollo A (1986) Evoked sacral potentials in subjects with true premature ejaculation. Andrologia 18: 583–586

    Article  CAS  PubMed  Google Scholar 

  26. Segraves RT, Saran A, Segraves K, Maguire E (1993) Clomipramine versus placebo in the treatment of premature ejaculation: a pilot study. J Sex Marital Ther 19: 198–200

    Article  CAS  PubMed  Google Scholar 

  27. Maniam P, Seftel AD, Cony EW, Rutchik SD, Hampel N, Althof SE (2001) Nocturnal penile tumescence activity unchanged after long-term intracavernous injection therapy. J Urol 165: 830–832

    Article  CAS  PubMed  Google Scholar 

  28. Waldinger MD, Hengeveld MW, Zwinderman AH (1994) Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 151: 1377–1379

    CAS  PubMed  Google Scholar 

  29. Mendels J, Camera A, Sikes C (1995) Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 15: 341–346

    Article  CAS  PubMed  Google Scholar 

  30. Kara H, Aydin S, Yucel M, Agargun MY, Odabas O, Yilmaz Y (1996) The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 156: 1631–1632

    Article  CAS  PubMed  Google Scholar 

  31. Seidman SN, Shabsigh R, Roose SP (1999) Pharmacologic treatment of sexual dysfunction. In: DL Dunner (ed): Psychiatric Clinics of North America: Annual of Drug Therapy. WB Saunders, Philadelphia, 21–33

    Google Scholar 

  32. Turner LA, Althof SE, Levine SB, Bodner DR, Kursh ED, Resnick MI (1992) Twelve-month comparison of two treatments for erectile dysfunction: self-injection versus external vacuum devices. Urology 39: 139–144

    Article  CAS  PubMed  Google Scholar 

  33. Nofzinger EA, Schwartz RM, Reynolds CF, Thase ME, Jennings JR, Frank E, Fasiczka AL, Garamoni GL, Kupfer DJ (1993) Correlation of nocturnal penile tumescence and daytime affect intensity in depressed men. Psychiatry Res 49: 139–150

    Article  CAS  PubMed  Google Scholar 

  34. Roose SP, Glassman AH, Walsh BT, Cullen K (1982) Reversible loss of nocturnal penile tumescence during depression: a preliminary report. Neuropsychobiology 8: 284–288

    Article  CAS  PubMed  Google Scholar 

  35. Steiger A, Holsboer F, Benkert O (1993) Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls. Acta Psychiatr Scand 87: 358–363

    Article  CAS  PubMed  Google Scholar 

  36. Thase ME, Reynolds CF, Jennings JR, Frank E, Howell JR, Houck PR, Berman S, Kupfer DJ (1988) Nocturnal penile tumescence is diminished in depressed men. Biol Psychiatry 24: 33–46

    Article  CAS  PubMed  Google Scholar 

  37. Fagan PJ, Schmidt CW, Wise TN, Derogatis LR (1988) Sexual dysfunction and dual psychiatric diagnoses. Compr Psychiatry 29: 278–284

    Article  CAS  PubMed  Google Scholar 

  38. Strand J, Wise TN, Fagan PJ, Schmidt CWJ (2002) Erectile dysfunction and depression: category or dimension? J Sex Marital Ther 28: 175–181

    Article  PubMed  Google Scholar 

  39. Shabsigh R, Klein LT, Seidman SN, Kaplan SA, Lehrhoff BJ, Ritter JS (1998) Increased incidence of depressive symptoms in men with erectile dysfunction. Urology 52: 848–852

    Article  CAS  PubMed  Google Scholar 

  40. Montgomery SA, Baldwin DS, Riley A (2002) Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 69: 119–140

    Article  CAS  PubMed  Google Scholar 

  41. Angulo J, Peiro C, Sanchez-Ferrer CF, Gabancho S, Cuevas P, Gupta S, Saenz de Tejada I (2001) Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. Br J Pharmacol 134: 1190–1194

    Article  CAS  PubMed  Google Scholar 

  42. Nurnberg HG, Seidman SN, Gelenberg AJ, Fava M, Rosen R, Shabsigh R (2002) Depression, antidepressant therapies, and erectile dysfunction: clinical trials of sildenafil citrate (Viagra) in treated and untreated patients with depression. Urology 60: 58–66

    Article  PubMed  Google Scholar 

  43. Price J, Grunhaus LJ (1990) Treatment of clomipramine-induced anorgasmia with yohimbine: a case report. J Clin Psychiatry 51: 32–33

    CAS  PubMed  Google Scholar 

  44. Reynolds RD (1997) Sertraline-induced anorgasmia treated with intermittent nefazodone [letter]. J Clin Psychiatry 58: 89

    Article  CAS  PubMed  Google Scholar 

  45. Lauerma H (1996) Successful treatment of citalopram-induced anorgasmia by cyproheptadine. Acta Psychiatr Scand 93: 69–70

    Article  CAS  PubMed  Google Scholar 

  46. Nelson EB, Keck PEJ, McElroy SL (1997) Resolution of fluoxetine-induced sexual dysfunction with the 5-HT3 antagonist granisetron [letter]. J Clin Psychiatry 58: 496–497

    Article  CAS  PubMed  Google Scholar 

  47. Balon R (1996) Intermittent amantadine for fluoxetine-induced anorgasmia. J Sex Marital Ther 22: 290–292

    Article  CAS  PubMed  Google Scholar 

  48. Labbate LA, Grimes JB, Hines A, Pollack MH (1997) Bupropion treatment of serotonin reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry 9: 241–245

    CAS  PubMed  Google Scholar 

  49. Landen M, Eriksson E, Agren H, Fahlen T (1999) Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol 19: 268–271

    Article  CAS  PubMed  Google Scholar 

  50. Roeloffs C, Bartlik B, Kaplan PM, Kocsis JH (1996) Methylphenidate and SSRI-Induced sexual side effects. J Clin Psychiatry 57: 548

    Article  CAS  PubMed  Google Scholar 

  51. Balon R (1999) Ginkgo biloba for antidepressant-induced sexual dysfunction? J Sex Marital Ther 25: 1–2

    CAS  PubMed  Google Scholar 

  52. Nurnberg HG, Hensley PL, Gelenberg AJ, Fava M, Lauriello J, Paine S (2003) Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA 289: 56–64

    Article  CAS  PubMed  Google Scholar 

  53. Michelson D, Bancroft J, Targum S, Kim Y, Tepner R (2000) Female sexual dysfunction associated with antidepressant administration: a randomized, placebo-controlled study of pharmacologic intervention. Am J Psychiatry 157: 239–243

    Article  CAS  PubMed  Google Scholar 

  54. Seidman SN, Pesce V, Roose SP (2000) High-dose Sildenafil Citrate for SSRI-associated Ejaculatory Delay: Open Clinical Trial. J Clin Psychiatry 2003; 64(6)

    Google Scholar 

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Seidman, S.N. (2004). Erectile dysfunction, depression, and pharmacological treatments: biologic interactions. In: Dunzendorfer, U. (eds) Sildenafil. Milestones in Drug Therapy MDT. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7945-3_7

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  • DOI: https://doi.org/10.1007/978-3-0348-7945-3_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9631-3

  • Online ISBN: 978-3-0348-7945-3

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