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Arachidonate Remodeling and Inflammation pp 61–72Cite as

Birkhäuser

Control of arachidonic acid levels in resting and activated U937 phagocytic cells by Ca2+-independent phospholipase A2

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Availability of free arachidonic acid (AA) is widely recognized as a rate-limiting step in the formation of prostaglandins. This fatty acid is an intermediate of a reacylation/deacylation cycle of membrane phospholipids, the so-called Lands pathway, in which the fatty acid is cleaved from phospholipid by phospholipase A2s (PLA2 ) and reincorporated by acyltransferases. Whereas in resting cells reacylation dominates, in stimulated cells the dominant reaction is the PLA2-mediated deacylation. Nevertheless, increased AA reacylation during cellular activation is still very significant, as manifested by the fact that only a minor portion of the free AA released by PLA2 is converted into eicosanoids, the remainder being effectively incorporated back into phospholipids.

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Author information

Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, University of Valladolid School of Medicine, Avenida Ramón y Cajal 7, E-47005, Valladolid, Spain

    Jesús Balsinde, Rebeca Pérez, Yolanda Sáez & María A. Balboa

Authors
  1. Jesús Balsinde
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  2. Rebeca Pérez
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  3. Yolanda Sáez
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  4. María A. Balboa
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Editor information

Editors and Affiliations

  1. Molecular Neurology Program, Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA, 91101-1830, USA

    Alfred N. Fonteh

  2. Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1016, USA

    Robert L. Wykle

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© 2004 Springer Basel AG

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Balsinde, J., Pérez, R., Sáez, Y., Balboa, M.A. (2004). Control of arachidonic acid levels in resting and activated U937 phagocytic cells by Ca2+-independent phospholipase A2 . In: Fonteh, A.N., Wykle, R.L. (eds) Arachidonate Remodeling and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7848-7_4

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  • DOI: https://doi.org/10.1007/978-3-0348-7848-7_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9594-1

  • Online ISBN: 978-3-0348-7848-7

  • eBook Packages: Springer Book Archive

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