Summary
The low energy X-ray emissions of 123I lead to large variations in activity measurements using an ionisation chamber. A copper filter 0.5mm thick removes these X-rays but only reduces the 159 keV emissions by 14%. However the ionisation chamber needs to be recalibrated for the copper filter attenuation. We outline a simple method using a measurement made on 99Tcm to determine the change in sensitivity of the ionisation chamber using the copper filter. With the copper filter, the variation of activity measurements when 123I is in a syringe compared to those in a vial is reduced from 80% to 3%. The ratio of the manufacturers stated activity to measured activity was 102% and 111% for two manufacturers respectively.
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References
Harris CC, Jaszczak RJ, Greer KL, Briner WH, Coleman RE. Effect of characteristic X-Rays on Assay of I-123 by Dose Calibrator. J Nucl Med 1984; 25: 1367–1370.
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© 1997 Springer Basel AG
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Thomson, W.H., Hesslewood, S.R., Hepplewhite, J., Parker, K., Perrin, B. (1997). Ionisation Chamber Measurements of I123 Using a Copper Filter. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_34
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_34
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7774-9
Online ISBN: 978-3-0348-7772-5
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