Summary
Labeled amino acids have been successfully used to image brain tumors with PET and SPET. This study deals with the question whether percutaneous irradiation produces changes in 3-[123I]iodo-L-α-methyltyrosine (IMT) uptake. 32 patients were investigated before, during, after radiotherapy and 4 weeks later using IMT-SPET. In high-grade tumors there was a significant decrease of the tumor-to-non-tumor activity ratio (T/N) after irradiation, whereas T/N remained unchanged in low-grade astrocytomas. It is concluded that IMT uptake by brain tumors could be used to identify responders from non-responders to radiotherapy.
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© 1997 Springer Basel AG
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Otto, L. et al. (1997). Brain Tumors — Effect of Radiation Therapy on Amino Acid Transport. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_3
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_3
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7774-9
Online ISBN: 978-3-0348-7772-5
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