Summary
In order to assess changes in myocardial blood flow and coronary reserve during dobutamine stress, 14 patients with coronary single vessel stenosis (> 70% by angiography) were examined by O-15 water positron emission tomography (PET) at rest and during maximal dobutamine stress (maximal dosis 40 µg/kg/min). Control regions (myocardium supplied by a normal artery) showed a 2.5 fold increase in myocardial blood flow during dobutamine stress due to a reduction of coronary resistance. In contrast, myocardial blood flow in regions supplied by a stenosed coronary artery did not increase significantly.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bol A., Melin J. A., Vannoverschelde J.-L., Baudhuin T., Vogelaers D., De Pauw M., Michel C., Luxen A., Labar D., Cogneau M., Robert A., Heyndrickx G. R. and Wijns W. Direct comparison of [13N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Circulation 1993; 87: 512–525.
De Bruyne B., Baudhuin T., Melin J. A., Pijls N. H., Sys S. U., Bol A., Paulus W. J., Heyndrickx G. R. and Wijns W. Coronary flow reserve calculated from pressure measurements in humans. Validation with positron emission tomography. Circulation 1994; 89: 1013–22.
Herrero P., Staudenherz A., Walsh J. F., Gropler R. J. and Bergmann S. R. Heterogeneity of myocardial perfusion provides the physiological basis of perfusable tissue index. J Nucl Med 1995; 36: 320–7.
Iida H., Rhodes C. G., de Silva R., Araujo L. I., Bloomfield P. M., Lammertsma A. A. and Jones T. Use of the left ventricular time-activity curve as a noninvasive input function in dynamic oxygen-15-water positron emission tomography. J Nucl Med 1992; 33: 166–977.
Iida H., Takahashi A., Tamura Y., Ono Y. and Lammertsma A. A. Myocardial blood flow: Comparison of oxygen-l5-water bolus injection, slow infusion and oxygen-l5carbon dioxide slow inhalation. J Nucl Med 1995; 36: 78–85.
Krivokapich J., Huang S.-C. and Schelbert H. R. Assessment of the effects of dobutamine on myocardial blood flow and oxidative metabolism in normal human subjects using nitrogen-13 ammonia and carbon-11 acetate. Am J Cardiol 1993; 71: 1351–1356.
Nitenberg A. and Antony I. Coronary vascular reserve in humans: a critical review of methods of evaluation and of interpretation of the results. Europ Heart J 1995; 16: 7–21.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Basel AG
About this chapter
Cite this chapter
Moka, D. et al. (1997). Quantitative Evaluation of Myocardial Blood Flow and Coronary Reserve in Patients with Coronary Artery Disease: A Dobutamine Stress — [O-15] H2O PET Study. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_24
Download citation
DOI: https://doi.org/10.1007/978-3-0348-7772-5_24
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7774-9
Online ISBN: 978-3-0348-7772-5
eBook Packages: Springer Book Archive