Summary
Early stages of dementia of Alzheimer type (DAT) often fail to show characteristic patterns of local cerebral blood flow (lCBF). The present study deals with the question whether characteristic lCBF deficits can be produced or enhanced by activation. 22 patients underwent vasomotor activation by 500 mg acetazolamide and 33 patients cognitive activation by labyrinth task prior to 500 MBq Tc-HMPAO administration. According to visual scoring vasomotor activation decreased the fraction of patients with abnormal patterns from 16/22 (73 %) to 7/22 (32 %.) In contrast, neuroactivation increased the number of definitely abnormal patient studies from 19 (58 %) to 27 (82 %) out of 33 studies.
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© 1997 Springer Basel AG
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Dannenberg, C., Marschall, B., Zedlick, D., Bettin, S., Seese, A., Knapp, W.H. (1997). Neuroactivation and Vasoactivation Studies in Patients with Impaired Cognitive Function Using Tc-99m-HMPAO-SPECT. In: Bergmann, H., Kroiss, A., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7772-5_15
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DOI: https://doi.org/10.1007/978-3-0348-7772-5_15
Publisher Name: Birkhäuser, Basel
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