Advertisement

The history of confounding

  • Jan P. Vandenbroucke

Summary

Confounding is a basic problem of comparability — and therefore has always been present in science. Originally a plain English word, it acquired more specific meanings in epidemiologic thinking about experimental and non-experimental research. The use of the word can be traced to Fisher. The concept was developed more fully in social science research, among others by Kish. Landmark developments in epidemiology in the second half of the 20th century were by Cornfield and by Miettinen. These developments emphasised that reasoning about confounding is almost entirely an a priori process that we have to impose upon the data and the data-analysis to arrive at a meaningful interpretation. The problems of confounding present their old challenges again in recent applications to genetic epidemiology.

Keywords

Wrong Information Professional Historian Baseline Prognosis Oral Glucose Lowering Landmark Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Basel AG 2004

Authors and Affiliations

  • Jan P. Vandenbroucke
    • 1
  1. 1.Clinical EpidemiologyLeiden University Medical CenterLeidenThe Netherlands

Personalised recommendations