The threshold of age in exercise and antioxidants action

  • Abraham Z. Reznick
  • Eric H. Witt
  • Michael Silbermann
  • Lester Packer
Part of the EXS book series (EXS, volume 62)


Physical activity and exercise are important factors in determining the quality of life in old animals and humans. With age there is a slow but significant reduction in muscle mass and ability to perform certain physical activities. This may be due to changes with the age of muscle composition and protein turnover, as well as decrease of trophic influence in neural control of muscles of old individuals. Exercise in general was shown to improve muscle performance even in old age. However a concept of threshold of age in exercise was advanced forward in the 1970s. Accordingly, the idea was that for a given exercise of a particular duration and intensity there is a certain age beyond which this exercise may not have a positive influence, but can become detrimental to the exercising animal or human.

Recent studies on the effect of antioxidants such as Vitamins C and E and selenium have shown that these agents could decrease the free radical associated muscle damage caused by extensive exercise. Thus, administration of these antioxidants especially vitamins C and E may reduce the oxidative damage due to exercise, and may alter the threshold of age by delaying it to an older age.


Muscle Mass Protein Carbonyl Protein Turnover Skeletal Muscle Mass Extensive Exercise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Abraham Z. Reznick
    • 1
  • Eric H. Witt
    • 2
  • Michael Silbermann
    • 1
  • Lester Packer
    • 2
  1. 1.Department of Morphological Sciences, The Bruce Rappaport Faculty of Medicine and the Rappaport Family Institute for Research in the Medical SciencesTechnion-Israel Institute of TechnologyHaifaIsrael
  2. 2.Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA

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