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Vitamin C and vitamin E — synergistic interactions in vivo?

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Free Radicals and Aging

Part of the book series: EXS ((EXS,volume 62))

Summary

The synergistic relationship between ascorbic acid (vitamin C) and α-tocopherol (vitamin E) in the inhibition of lipid peroxidation has been known for some time and is now well established in vitro systems. The possibility that ascorbic acid may also reduce tocopheroxyl radicals in vivo is a subject of some interest and speculation. Although not all experiments have failed to suggest a synergistic antioxidant interaction, recent data indicate that the postulated synergism between these vitamins might be relatively unimportant compared with other metabolic processes.

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References

  • Arad, J. D., Dgani, Y., and Eyal, F. G. (1985) Vitamin E and vitamin C plasma levels in premature infants following supplementation of vitamin C. Internat. J. Vit. Nutr. Res. 55: 395–397.

    CAS  Google Scholar 

  • Bast, A., and Haenen, G. R. M. M. (1990) Regulation of lipid peroxidation by glutathione and lipoic acid: involvement of liver microsomal vitamin E free radical reductase, in: Antioxidants in Therapy and Preventive Medicine, I. Emerit et al., eds. Plenum Press, New York, pp. 111–116.

    Chapter  Google Scholar 

  • Behrens, W. A., and Madere, R. (1989) Ascorbic and dehydroascorbic acids status in rats fed diets varying in vitamin E levels. Internat. J. Vit. Nutr. Res. 59: 360–364.

    CAS  Google Scholar 

  • Bendich, A., D’Apolito, P., Gabriel, E., and Machlin, L. J. (1984) Interaction of dietary vitamin C and vitamin E on guinea-pig immune responses to mitogens. J. Nutr. 114: 1588–1593.

    PubMed  CAS  Google Scholar 

  • Borek, C. (1991) Free-radical process in multistage carcinogenesis. Free Rad. Res. Comms. 12–13: 745–750.

    Article  Google Scholar 

  • Burton, G. W., Wronska, U., Stone, L., Foster, D. O., and Ingold, K. U. (1990) Biokinetics of dietary RRR-a-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not “spare” vitamin E in vivo. Lipids 25: 199–210.

    CAS  Google Scholar 

  • Chan, A. C., Tran, K., Raynor, T., Ganz, P. R., and Chow, C. K. (1991) Regeneration of vitamin E in human platelets. J. Biol. Chem. 266: 17290–17295.

    PubMed  CAS  Google Scholar 

  • Chen, L. H., and Chang, H. M. (1979) Effects of high level of vitamin C on tissue antioxidant status of guinea pigs. Internat. J. Vit. Nutr. Res. 49: 87–91.

    CAS  Google Scholar 

  • Chen, L. H., and Thacker, R. R. (1987) Effect of ascorbic acid and vitamin E on biochemical changes associated with vitamin E deficiency in rats. Internat. J. Vit. Nutr. Res. 57: 385–390.

    CAS  Google Scholar 

  • Chen, L. H. (1981) An increase in vitamin E requirement induced by high supplementation of vitamin C in rats. Am. J. CHn. Nutr. 34: 1036–1041.

    CAS  Google Scholar 

  • Frei, B., Stocker, R., England, L., and Ames, B. M. (1990) Ascorbate: the most effective antioxidant in human blood plasma, in: Antioxidants in Therapy and Preventive Medicine. I. Emerit et al., eds. Plenum Press, New York, pp. 155–163.

    Chapter  Google Scholar 

  • Hruba, F., Novakova, V., and Ginter, E. (1982) The effect of chronic marginal vitamin C deficiency on the alpha-tocopherol content of the organs and plasma of guinea-pigs. Experientia 38: 1454–1455.

    Article  PubMed  CAS  Google Scholar 

  • Jialal, I., and Grundy, S. M. (1991) Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification. J. Chn. Invest. 87: 597–601.

    Article  CAS  Google Scholar 

  • Kagan, V. E., Serbinova, E. A., and Packer, L. (1990) Recycling and antioxidant activity of tocopherol homologs of differing hydrocarbon chain lengths in hver microsomes. Arch. Biochem. Biophys. 282: 221–225.

    Article  PubMed  CAS  Google Scholar 

  • McCay, P. B. (1985) Vitamin E: Interactions with free radicals and ascorbate. Ann. Rev. Nutr. 5: 323–340.

    Article  CAS  Google Scholar 

  • Mulholland, C. W., and Strain, J. J. (1991) Effect of antioxidant vitamin supplementation on the peroxyl radical trapping abihty of plasma. Proc. Nutr. Soc. 50: 133A.

    Google Scholar 

  • Niki, E., Tsuchiya, J., Tanimura, R., and Kamiya, Y. (1982) Regeneration of vitamin E from a-chromonoxy radical by glutathione and vitamin C. Chem. Lett., 789–792.

    Google Scholar 

  • Niki, E. (1991) Vitamin C as an antioxidant. World Rev. Nutr. Diet. 64: 1–30.

    PubMed  CAS  Google Scholar 

  • Packer, J. E., Slater, T. F., and Willson, R. L. (1979) Direct observation of a free radical interaction between vitamin E and vitamin C. Nature, Lond. 278: 737–738.

    Article  CAS  Google Scholar 

  • Packer, L., and Landvik, S. (1990) Vitamin E in biological systems, in: Antioxidants in Therapy and Preventive Medicine. I. Emerit et al., eds. Plenum Press, New York, pp. 93–103.

    Google Scholar 

  • Packer, L., Maguire, J. J., Mehlorn, R. J., Serbinova, L., and Kagan, V. E. (1989) Mitochondria and microsomal enzymes have a free radical reductase activity that prevents chromanoxyl radical accumulation. Biochem. Biophys. Res. Comms., 159: 229–235.

    Article  CAS  Google Scholar 

  • Sato, K., Niki, E., and Shimasaki, H. (1990) Free radical-mediated chain oxidation of low density hpoprotein and its synergistic inhibition by vitamin E and vitamin C. Arch. Biochem. Biophys. 279: 402–405.

    Article  PubMed  CAS  Google Scholar 

  • Van den Berg, J. J. M., Kuypers, F. A., Roelofsen, B., and Op den Kamp, J. A. F. (1990) The cooperative action of vitamins E and C in the protection against peroxidation of parinaric acid in human erythrocyte membranes. Chem. Phys. Lipids 53: 309–320.

    Article  PubMed  Google Scholar 

  • Vatassery, G. T., Smith, W. E., and Quach, H. T. (1989) Ascorbic acid, glutathione and synthetic antioxidants prevent the oxidation of vitamin E in platelets. Lipids 24: 1043–1047.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, D. D. M., Burton, G. W., Inpld, K. U., Barclay, L. R. C., and Locke, S. J. (1987) The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical trapping antioxidant activity of human blood plasma. Biochim. Biophys. Acta 92: 408–419.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Human Nutrition Research Group, University of Ulster, BT52 1SA, Coleraine, Northern Ireland

    J. J. Strain & C. W. Mulholland

  2. Ulster Hospital, BT16 ORH, Dundonald, Belfast, Northern Ireland

    C. W. Mulholland

Authors
  1. J. J. Strain
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  2. C. W. Mulholland
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Editor information

Editors and Affiliations

  1. C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, 15–21, Rue de l’Ecole de Médecine, F-75006, Paris, France

    Ingrid Emerit (Directeur de Recherche) (Directeur de Recherche)

  2. Department of Biochemistry and Biophysics, University of Pennsylvania, D-501 Richards Building, 19104-6089, Philadelphia, PA, USA

    Britton Chance

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Strain, J.J., Mulholland, C.W. (1992). Vitamin C and vitamin E — synergistic interactions in vivo?. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_40

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  • DOI: https://doi.org/10.1007/978-3-0348-7460-1_40

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7462-5

  • Online ISBN: 978-3-0348-7460-1

  • eBook Packages: Springer Book Archive

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