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Age-related variations of enzymatic defenses against free radicals and peroxides

  • Yves Artur
  • Bernard Herbeth
  • Laila Guémouri
  • Edith Lecomte
  • Claude Jeandel
  • Gérard Siest
Part of the EXS book series (EXS, volume 62)

Summary

Superoxide dismutase, glutathione peroxidase and catalase are the three main enzymatic systems of defense of the organism against free radicals and peroxides. A survey of the literature shows that no general tendency of evolution of these systems in aging emerges, even if some recent studies in humans demonstrate the existence of a concomitant decrease in most of the antioxidant enzymes in blood of the elderly. The study of the antioxidant systems and their interrelations in the elderly represents a large field of future investigations.

Keywords

Antioxidant Enzyme Superoxide Dismutase Glutathione Peroxidase Antioxidant Enzyme Activity Free Radical Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Campbell, D., Bunker, V. W., Thomas, A. J., and Clayton, B. E. (1989) Selenium and vitamin E status of healthy and institutionalized elderly subjects: Analysis of plasma, erthyrocytes and platelets. Br. J. Nutr. 62: 221–227.PubMedCrossRefGoogle Scholar
  2. Cand, F., and Verdeti, J. (1989). Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation in the major organs in the aging rats. Free Radical Biol. Med. 7: 59–63.CrossRefGoogle Scholar
  3. Del Maestro, R., and McDonald, W. (1987) Distribution of superoxide dismutase, glutathione peroxidase and catalase in developing rat brain. Mech. Aging Dev. 41: 29–38.PubMedCrossRefGoogle Scholar
  4. Guémouri, L., Artur, Y., Herbeth, B., Jeandel, C., Cuny, G., and Siest, G. (1991a) Biological variability of superoxide dismutase, glutathione peroxidase, and catalase in blood. Clin. Chem. 37: 1932–1937.PubMedGoogle Scholar
  5. Guémouri, L., Herbeth, B., Artur, Y., Jeandel, C., and Siest, G. (1991b) Weak relationships between blood antioxidant enzymes and serum lipids or apohpoproteins. J. Int. Med. 229: 297–299.CrossRefGoogle Scholar
  6. Gutman, R. L., Cohen, M. R., McAmis, W., Ramchand, C. N., and Sailer, V. (1987) Free radical scavenging systems and the effect of peroxide damage in aged human skin fibroblasts. Exp. Gerontol. 22: 373–378.PubMedCrossRefGoogle Scholar
  7. Harman, D. (1988) Free radicals in aging. Mol. Cell. Biochem. 84: 155–161.PubMedCrossRefGoogle Scholar
  8. Hazelton, G. A., and Lang, C. A. (1985) Glutathione peroxidase and reductase activities in the aging mouse. Mech. Aging Dev. 29: 71–81.PubMedCrossRefGoogle Scholar
  9. Hotz, P., Hoet, P., and Lauwerys, R. (1987) Peroxydation lipidique en pathologie humaine: Evaluation des données de la littérature. Path. Biol. 35: 1067–1073.Google Scholar
  10. Ji, L. L., Dillon, D., and Wu, E. (1990) Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver. Am. J. Physiol. 258: R918-R923.PubMedGoogle Scholar
  11. Jozwiak, Z., and Jasnowska, B. (1985) Changes in oxygen-metaboHzing enzymes and lipid peroxidation in human erythrocytes as a function of age of donor. Mech. Aging Dev. 32: 77–83.PubMedCrossRefGoogle Scholar
  12. Kellog, E. W., and Fridovich, L (1976) Superoxide dismutase in the rat and mouse as a function of age and longevity. J. Gerontol. 31: 405–408.Google Scholar
  13. Laganière, S., and Yu, B. P. (1989) Effect of chronic food restriction in aging rats. II. Liver cytosolic antioxidants and related enzymes. Mech. Aging Dev. 48: 221–230.PubMedCrossRefGoogle Scholar
  14. Marklund, S. L. (1984) Extracellular-superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammahan species. Biochem. J. 222: 649–655.PubMedGoogle Scholar
  15. Mote, P. L., Grizzle, J. M., Walford, R. I., and Spindler, S. R. (1990) Age-related down regulation of hepatic cytochrome PI-450, P3–450, catalase and CuZn-superoxide dismutase RNA. Mech. Aging Dev. 53: 101–110.PubMedCrossRefGoogle Scholar
  16. Neve, J., Vertongen, F., Peretz, A., and Carpentier, Y. A. (1989) Valeurs usuelles du sélénium et de la glutathion peroxidase dans une population belge. Ann. Biol. Clin. 47: 138–143.Google Scholar
  17. Perrin, R., Briançon, S., Jeandel, C., Artur, Y., Minn, A., Penin, F., and Siest, G. (1990) Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer’s disease: A case-control study. Gerontology 36: 306–313.PubMedCrossRefGoogle Scholar
  18. Pinto, R. E., and Bertley, W. (1969) The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochem. J. 112: 109–115.PubMedGoogle Scholar
  19. Pryor, W. A. (1987) The free-radical theory of aging revisited: A critique and a suggested disease - specific theory, in: Modem Biological Theories of Aging, H. R. Warner, R. N. Butler, R. L. Sprott and E. L. Schneider, pp. 89–112. Eds Raven Press Publ., New York.Google Scholar
  20. Rao, C., Xia, E., and Richardson, A. (1990a) Effect of age on the expression of antioxidant enzymes in male Fischer F 344 rats. Mech. Aging Dev. 53: 49–60.PubMedCrossRefGoogle Scholar
  21. Rao, G., Xia, E., Nadakavukaren, M. J., and Richardson, A. (1990b) Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat hver. J. Nutr. 120: 602–609.PubMedGoogle Scholar
  22. Schäfer, L., and Thorling, E. B. (1990) Lipid peroxidation and antioxidant supplementation in old age. Scand. J. Chn. Lab. Invest. 50: 69–75.CrossRefGoogle Scholar
  23. Semsei, L, Rao, G., and Richardson, A. (1989) Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction. Biochem. Biophys. Res. Commun. 164: 620–625.PubMedCrossRefGoogle Scholar
  24. Sohal, R. S. (1989) Oxidative stress hypothesis of aging, in: Advances in Myochemistry, 2nd edn, pp. 21–34. Ed. G. Benzi. John Libbey Publ., London.Google Scholar
  25. Sohal, R. S., Sohal, B. H., and Brunk V. T. (1990) Relationship between antioxidant defenses and longevity in different mammalian species. Mech. Aging Dev. 53: 217–227.PubMedCrossRefGoogle Scholar
  26. Vertechy, M., Cooper, M. B., Ghirardi, O., and Ramacci, M. T. (1989). Antioxidant enzyme activities in heart and skeletal muscle of rats of different ages. Exp. Gerontol. 24: 211–218.PubMedCrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Yves Artur
    • 1
  • Bernard Herbeth
    • 1
    • 2
  • Laila Guémouri
    • 1
  • Edith Lecomte
    • 1
  • Claude Jeandel
    • 3
  • Gérard Siest
    • 1
  1. 1.Centre de Médecine PréventiveVandoeuvre-lès-NancyFrance
  2. 2.Faculté de MédecineINSERM U115Vandoeuvre-lès-NancyFrance
  3. 3.Service de Médecine Interne BCentre Hospitalier Régional UniversitaireVandoeuvre-lès-NancyFrance

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