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Possible role of free radicals in the chronic inflammation of the gut

  • Toshikazu Yoshikawa
  • Shuji Takahashi
  • Motoharu Kondo
Part of the EXS book series (EXS, volume 62)

Summary

Recent studies have demonstrated that intracolonic administration of trinitroben-zenesulfonic acid (TNB) dissolved in ethanol produces chronic colitis in rats, and that this model shares many features of human inflammatory bowel disease (IBD), particularly Crohn’s disease. We investigated the role of free radicals in the pathogenesis of this cohtis model. In the early stage of this colitis, antioxidant enzymes (such as superoxide dismutase, glutathione peroxidase) and an antioxidant, µ-tocopherol, were significantly decreased with the severity of colonic damage. Mn-SOD at a dose of 50000 U/kg attenuated this colitis when preadministered subcutaneously one hour before the induction of colitis. These results suggest that oxygen-derived free radicals may play an important role in this colitis.

Keywords

Inflammatory Bowel Disease Distal Colon Damage Score Colonic Lesion Colonic Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Toshikazu Yoshikawa
    • 1
  • Shuji Takahashi
    • 1
  • Motoharu Kondo
    • 1
  1. 1.First Department of MedicineKyoto Prefectural University of MedicineKamigyo-ku, Kyoto 620Japan

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