Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid

  • Alan J. Sinclair
  • Joseph Lunec
  • Alan J. Girling
  • Anthony H. Barnett
Part of the EXS book series (EXS, volume 62)


Free radical mechanisms are increasingly being implicated in the pathogenesis of tissue damage in diabetes. Various sources of free radicals may modulate oxidative stress in diabetes, including non-enzymatic glycosylation of proteins and monosaccharide autooxidation, polyol pathway activity, indirect production of free radicals through cell damage from other causes, and reduced antioxidant reserve. Ascorbic acid, which may be a principal modulator of free radical activity in diabetes, is shown to be consumed, presumably through free radical scavenging, thus preserving levels of other antioxidants such as glutathione.


Ascorbic Acid Aldose Reductase Diene Conjugate Polyol Pathway Dehydroascorbic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Alan J. Sinclair
    • 1
  • Joseph Lunec
    • 2
  • Alan J. Girling
    • 3
  • Anthony H. Barnett
    • 4
  1. 1.University Department of Geriatric MedicineUniversity of Wales College of MedicineCardiffUK
  2. 2.Wolfson LaboratoriesUniversity of BirminghamUK
  3. 3.Department of Mathematics and StatisticsUniversity of BirminghamUK
  4. 4.Department of MedicineUniversity of BirminghamUK

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