DNA damage in mammalian cell lines with different antioxidant levels and DNA repair capacities

  • Bernadette M. Hannigan
  • Shirley-Ann M. Richardson
  • P. Gerald McKenna
Part of the EXS book series (EXS, volume 62)


A wide range of DNA damage is known to be caused by reactive oxygen species (ROS). Defence against the effects of such damage include damage prevention (e.g. antioxidant activity) and the removal of damaged moieties from DNA (DNA repair). Radiation (X-ray) sensitive murine lymphoma (LY) cells were seen to be more susceptible to ROS-induced damage than were radiation resistant cells. This difference was unlikely to be due to the marginally decreased DNA excision repair capacity of the sensitive cells. Radiation sensitive cells did, however, have lower endogenous antioxidant enzyme levels. Thus, the importance of assessing all levels of a cell’s response to ROS, in determining the major factors leading to increased mutagen sensitivity, is emphasised.


Reactive Oxygen Species Excision Repair L5178Y Cell Murine Lymphoma Cell L5178Y Mouse Lymphoma 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Bernadette M. Hannigan
    • 1
  • Shirley-Ann M. Richardson
    • 1
  • P. Gerald McKenna
    • 1
  1. 1.Biomedical Sciences Research Centre, Department of Biological and Biomedical SciencesUniversity of UlsterColeraineNorthern Ireland

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