Free radicals, lipid peroxidation, SOD activity, neurotransmitters and choline acetyltransferase activity in the aged rat brain

  • M. Hiramatsu
  • R. Edamatsu
  • A. Mori
Part of the EXS book series (EXS, volume 62)


The mechanism of aging is suggested to be related to oxygen free radicals. Free radicals, lipid peroxidation and SOD activity have been reported to be increased in the aged brain. A Japanese herbal medicine, Sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960), which has scavenging activities against hydroxyl radicals, superoxide, l,l-diphenyl-2-picrylhydrazyl radicals, carbon-centered radicals and alpha-tocopheroxyl radicals, decreased carbon-centered radicals and thiobarbituric acid reactive substances (TBARS) levels in the aged rat brain after a 3-week oral administration of 5% TJ-960 solution. TJ-960 elevated superoxide dismutase (SOD) activity in the cytosol fraction of the hippocampus and hypothalamus of aged rats. It decreased norepinephrine and 5-hydroxytryptamine (5-HT) levels in the hypothalamus and increased the 5-HT level in the cerebellum. TJ-960 treatment increased choline acetyltransferase activity in aged rats. As herbal medicines do not generally have harmful side effects, antioxidant TJ-960 appears to be a suitable prophylactic agent against some neuronal symptoms of aging.


Down Syndrome Human Cerebrospinal Fluid Japanese Herbal Medicine Spin Trap Method Choline Acetyltrans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • M. Hiramatsu
    • 1
  • R. Edamatsu
    • 2
  • A. Mori
    • 2
  1. 1.Yamagata Technopolis FoundationYamagata 990Japan
  2. 2.Department of Neuroscience, Institute of Molecular and Cellular MedicineOkayama University Medical SchoolOkayama 700Japan

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