Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro

  • Daniel Boscoboinik
  • Eric Chatelain
  • Gianna-M. Bartoli
  • Angelo Azzi
Part of the EXS book series (EXS, volume 62)


The molecular events responsible for the inhibition of cell proliferation by α-tocopherol have been investigated. Smooth muscle cells in vitro have been shown to be specifically inhibited by α-tocopherol with a concomitant inhibition of protein kinase C activity.β-Tocopherol was inactive, despite its similar radical scavenging activity. The point of inhibition of α-tocopherol relative to the cell cycle was localized in the late G1 phase. A second effect of α-tocopherol observed with smooth muscle cells was the stimulation of protein kinase C biosynthesis in both the S and G2 phases of the cell cycle. The implications of these findings for the onset of arteriosclerosis are discussed.


Smooth Muscle Cell Vascular Smooth Muscle Cell Smooth Muscle Cell Proliferation Arterial Smooth Muscle Cell Liquid Scintillation Analyzer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



fetal calf serum




phorbol dibutyrate


plateletderived growth factor


protein kinase C


vascular smooth muscle cells.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1992

Authors and Affiliations

  • Daniel Boscoboinik
    • 1
  • Eric Chatelain
    • 1
  • Gianna-M. Bartoli
    • 1
  • Angelo Azzi
    • 1
  1. 1.Institut für Biochemie und MolekularbiologieUniversität BernBernSwitzerland

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