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Influence of Neonatal Nicotine Exposure on Development of Nicotinic Receptor Subtypes in Brain and Behaviour in Adult Mice

  • Chapter
Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

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Summary

Neonatal exposure of nicotine influences the development of nicotinic receptor subtypes in brain. The displacement curves of [3H]nicotine/(−)nicotine in adult mice cortex indicate both high and low affinity nicotinic binding sites for saline treated animals, while only high affinity nicotinic binding site for neonatally nicotine treated animals. Neonatal nicotine exposure also changes the behavioural effect of nicotine in adult mice.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Uppsala University, Uppsala, Sweden

    Xiao Zhang & Agneta Nordberg

  2. Department of Zoophysiology, Uppsala University, Uppsala, Sweden

    Per Eriksson

  3. Department of Toxicology, Uppsala University, Uppsala, Sweden

    Anders Fredriksson

Authors
  1. Xiao Zhang
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  2. Per Eriksson
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  3. Anders Fredriksson
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  4. Agneta Nordberg
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Zhang, X., Eriksson, P., Fredriksson, A., Nordberg, A. (1991). Influence of Neonatal Nicotine Exposure on Development of Nicotinic Receptor Subtypes in Brain and Behaviour in Adult Mice. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_59

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_59

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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