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Nicotine-Induced Release of Noradrenaline and Neuropeptide Y in the Heart: Dependence on Calcium, Potassium, and pH

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

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Summary

Dependence of nicotine-induced noradrenaline and neuropeptide Y release on extracellular calcium, potassium, and pH has been investigated in isolated perfused guinea pig hearts. Noradrenaline and neuropeptide Y were determined by high pressure liquid chromatography and by a specific radioimmunoassay, respectively. Nicotine (1–100 µmol/1) induced a concentration dependent release of both sympathetic transmitters. The release was absolutely dependent on the extracellular presence of calcium. Reduction of extracellular potassium resulted in a markedly increased overflow of noradrenaline and neuropeptide Y. A rise of potassium above physiological levels caused a suppression of the release. Likewise, a rise of extracellular proton concentrations caused a reduction of noradrenaline and neuropeptide Y release.

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Authors and Affiliations

  1. Department of Cardiology, University of Heidelberg, Germany

    G. Richardt, M. Haass, Th. Brenn & A. Schömig

  2. Department of Pharmacology, University of Würzburg, Germany

    E. Schömig

Authors
  1. G. Richardt
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  2. M. Haass
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  3. Th. Brenn
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  4. E. Schömig
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  5. A. Schömig
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Richardt, G., Haass, M., Brenn, T., Schömig, E., Schömig, A. (1991). Nicotine-Induced Release of Noradrenaline and Neuropeptide Y in the Heart: Dependence on Calcium, Potassium, and pH. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_28

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_28

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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