Summary
Exposure to either nonactivating (nM) or activating (µM) concentrations of nicotine desensitized nicotine-stimulated [3H]dopamine release from striatal synaptosomes and 86Rb+ efflux from thalamic synaptosomes, but the kinetics of desensitization were not identical. Although nicotine-stimulated 86Rb+ efflux was completely inhibited by exposure to either low or high concentrations of nicotine, a significant fraction of [3H]dopamine release persisted. The kinetics of functional desensitization was similar to that for high affinity [3H]nicotine binding.
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© 1995 Birkhäuser Verlag Basel
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Marks, M.J., Grady, S.R., Robinson, S.F., Bullock, A.E., Collins, A.C. (1995). Biochemical Measures of Nicotinic Receptor Desensitization. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_9
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DOI: https://doi.org/10.1007/978-3-0348-7445-8_9
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