Summary
We are studying factors that influence the expression of neuronal nicotinic acetylcholine receptors (nAChR) in rat sympathetic neurons. We find that: 1) nAChR genes are differentially regulated during postnatal development; 2) the developmental increase in α3 mRNA levels correlate with the increase in ACh-current densities; 3) activity induces α7 subunit gene expression and increases α-bungarotoxin (α-BGT) binding; 4) choline is a ligand for α7 receptors in Xenopus oocytes. Finally, we speculate on a possible function for the α-BGT receptor (α-BGTR) in sympathetic ganglia.
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© 1995 Birkhäuser Verlag Basel
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De Koninck, P., Cooper, E. (1995). Factors Controlling Nicotinic Acetylcholine Receptor Expression on Rat Sympathetic Neurons. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_17
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DOI: https://doi.org/10.1007/978-3-0348-7445-8_17
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