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Potential Role of Protein Oxidation and Proteasome in Antigen Processing

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Oxidative Stress, Cell Activation and Viral Infection

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

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Summary

The hypothesis is presented that in antigen presenting cells, normal background rates of protein oxidation may supply endogenous protein substrates for the 19S proteasome proteolytic complex. Certain antigen presenting cells, such as macrophages, may actually use an oxidative burst to “mark” endogenous cytoplasmic proteins for partial degradation by the 19S proteasome. Proteasome seems to be able to generate peptides of approximately nine amino acids in length, which can combine with major histocompatibility complex (MHC) class I molecules and β2-microglobulin. Such MHC class I antigen complexes next appear to migrate through the endoplasmic reticulum and the Golgi apparatus, assisted by specific ABC (ATP-binding cassette) superfamily transporter proteins, to the cell surface. Thus antigen presenting cells may use oxidative marking (either from background protein oxidation, or through an oxidative burst) of precursor self-antigens to direct cell surface class I presentation for surveillance by CD8+T cells.

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Authors and Affiliations

  1. Department of Biochemistry & Molecular Biology, The Albany Medical College, Albany, New York, 12208, USA

    K. J. A. Davies

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  1. K. J. A. Davies
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Editors and Affiliations

  1. INSERM U. 294, 16, rue Henri Huchard, F-75018, Paris, France

    C. Pasquier

  2. Dept. SIDA & Rétrovirus, Unité d’Oncologie Virale, 25-28, rue du Dr. Roux, F-75015, Paris, France

    R. Y. Olivier

  3. Institut Gustave Roussy, INSERM U. 140, 39, rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    C. Auclair

  4. Dept. of Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    Lester Packer

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Davies, K.J.A. (1994). Potential Role of Protein Oxidation and Proteasome in Antigen Processing. In: Pasquier, C., Olivier, R.Y., Auclair, C., Packer, L. (eds) Oxidative Stress, Cell Activation and Viral Infection. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7424-3_2

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  • DOI: https://doi.org/10.1007/978-3-0348-7424-3_2

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7426-7

  • Online ISBN: 978-3-0348-7424-3

  • eBook Packages: Springer Book Archive

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