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Electrophysiology of Calcium Channels in Airways Smooth Muscle

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Book cover Airways Smooth Muscle: Development, and Regulation of Contractility

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

In 1979, Bolton [1] proposed that one of the routes by which Ca2+ might gain entry into smooth muscle cells comprised a channel in the cell membrane the opening of which was voltage-dependent. It was envisaged that this channel would pass current during the depolarizing phase of the regenerative action potential or, in those cells not capable of supporting action potential discharge, during graded depolarization of the cell membrane. It was further envisaged that the voltage-dependent channel was relatively specific for Ca2+ and was susceptible to blockade by organic inhibitors of Ca2+ influx such as the phenylalkylamine, verapamil, or the dihydropyridine, nifedipine.

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Authors and Affiliations

  1. Smooth Muscle Research Group, School of Biological Sciences, University of Manchester, Manchester, England

    Roger C. Small & Robert W. Foster

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  1. Roger C. Small
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  2. Robert W. Foster
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Editors and Affiliations

  1. Discovery Biology, Rhône-Poulenc Rorer Ltd, Dagenham Research Centre, RM10 7XS, Dagenham, Essex, England

    David Raeburn (Department Head) (Department Head)

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Small, R.C., Foster, R.W. (1994). Electrophysiology of Calcium Channels in Airways Smooth Muscle. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Development, and Regulation of Contractility. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7408-3_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7408-3_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7410-6

  • Online ISBN: 978-3-0348-7408-3

  • eBook Packages: Springer Book Archive

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