Summary
In MRL-lpr/lpr (MRL/1) mice developing the SLE-like autoimmune disorder, PQQ can modulate many features of the pathological process including immune functions. The mean survival time was extended; enlargements of lymphoid organs and also of the liver were reduced; titres of anti-double stranded (ds) DNA antibodies and concentrations of serum amyloid P component (SAP) were reduced; serum IgG levels were not changed; T cell mitogenic responses to concanavalin A (con A) were enhanced, whereas B cells stimulated with lipopolysaccharide (LPS) were not. The results suggest that PQQ partly inhibits the development of the SLE-like disease in MRL/1 mice, probably by reducing inflammation and influencing T cell differentiation.
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© 1994 Birkhäuser Verlag Basel/Switzerland
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Weimann, B.J. (1994). Effect of pyrroloquinoline quinone (PQQ) on the SLE-like (Systemic Lupus Erythematosus) disease in MRL-Ipr/Ipr mice. In: Marino, G., Sannia, G., Bossa, F. (eds) Biochemistry of Vitamin B6 and PQQ. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7393-2_56
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DOI: https://doi.org/10.1007/978-3-0348-7393-2_56
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7395-6
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