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Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction pp 233–254Cite as

Sodium/Hydrogen Exchange

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Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

The Na+/H+ exchanger (formerly antiporter) is widely distributed in nature as a component of the cell membrane. The cytosolic pH of tracheal smooth muscle, similar to many other mammalian tissues, is regulated by at least three known sarcolemmal processes. These processes include 1) the Na+/H+ exchanger, 2) the anion transporter requiring Cl−/HCO3 − and 3)H+ extruding, sodium-dependent anion transporter (Figure 1). The two sodium-dependent processes alkalinize the cells while the anion exchanger acidifies alkalotic cells. Together, these pH regulating systems maintain the cytosolic pH (intracellular pH, pHi) at a much higher value (7.0 to 7.3) than would be predicted by thermodynamic equilibrium calculated from the Nernst equation based on the membrane potential and passive distribution of H+ across the cell membrane. For example the resting membrane potential (Em) of canine tracheal smooth muscle was found to be —60 ± 1 mV [1]. Based on this, the calculated pH value at 37°C is expected to be 6.42, 0.6 pH units lower than the observed resting pHi, for adult canine trachealis. In sodium-free Hepes-buffered medium the pHi of the tracheal muscle is decreased by 0.5 pH unit [2]. Thus sodium-dependent intracellular pH regulating mechanisms are important in this tissue.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada

    Ratna Bose

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Editors and Affiliations

  1. Dagenham Research Centre, Discovery Biology Rhône-Poulenc Rorer Ltd, RM10 7XS, Dagenham, Essex, England

    David Raeburn (Department Head) (Department Head)

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Bose, R. (1995). Sodium/Hydrogen Exchange. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7362-8_11

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  • DOI: https://doi.org/10.1007/978-3-0348-7362-8_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7364-2

  • Online ISBN: 978-3-0348-7362-8

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