Skip to main content
SpringerLink
Log in

Tumor Imaging Using a Tc-99m Labelled Immunomodulatorresults of Clinical Studies in Various Kinds of Malignant Tumors

  • Chapter
Radioactive Isotopes in Clinical Medicine and Research

Part of the book series: Advances in Pharmacological Sciences ((APS))

  • 99 Accesses

Summary

Uptake of an immunomodulator extracted from bacterium Nocardia opaca and labelled by Tc-99m was found in animal tumors as Walker carcinosarcomas. Experiences with detection of malignant tumors in men are reported. In 105 pts. suffering from different types of malignomas sensitivity of tumor scintigraphy of 97% was found if a cutoff of 1.30 for ratio tumor/ background radioactivity was chosen. The uptake seems to be correlated with tumor proliferation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Miesel RS, Körner S, Haas R, Spinnler c, Ehrenfeld U, Weser U. Phagocytic response modifying reactivity of Nocardia opaca. Immunology Letters 1990; 26: 31–36

    Article  PubMed  CAS  Google Scholar 

  2. Ehrenfeld U, German patent P 3510795

    Google Scholar 

  3. Spinnler C, Huber G, Haas R, Ehrenfeld U, Zimmermann U. Lokale Immunreaktion mit Nekroseinduktion in soliden Karzinosarkomen der Ratte nach lokaler Anreicherung von systemisch appliziertem Nocardia opaca- Zellwandextrakt. Dtsch Zschr Onkol 1993; 25, 3: 70–72

    Google Scholar 

  4. Schümichen C, Weiß H. Tumor: Localization and biodistribution of 99mTc-muramylpolypeptide(MPP) in the rat. Nucl Med 1986; 25: 28–30

    Google Scholar 

  5. Schümichen C. Labeled immunomodulator from Nocardia bacteria, a new approach in tumordetection in current applications. In : Radiopharmacology. Proceedings of the fourth international symposium on radiopharmacology. Billinghurst MW editor. Tóronto, Oxford, New York, Sydney, Frankfurt: Pergamon Press, 1986: 62–66

    Google Scholar 

  6. Schümichen C. IMM(Immunomodulator) a new approach in radioimmunodetection of malign tumors. In: European Nuclearmedicine Congress 1985 London, Sept 3–6. Schmidt HAE, Ell PJ, Britton ICE editors. Stuttgart, New York: F.K.Schattauer, 1986: 418–420

    Google Scholar 

  7. Wagner HN. Oncology: A new engine for PET/SPECT. J Nucl Med 1993; 34: 13N - 32N

    PubMed  Google Scholar 

  8. Franke WG, Schmiedel Th, Grundmann A, Pöpel U, Pöpel Ute, Schomäcker K, Gössel J. Early clinical experiences in tumor diagnosis with radioactive lanthanide complexes. Nucl Med 1993; 32: 188–193

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Nuklearmedizin, Germany

    W.-G. Franke

  2. Institut für Medizinische Informatik und Biometrie, Germany

    R. Koch

  3. JOMOL Pharma (GmbH) Regensburg, Germany

    U. Ehrenfeld, R. Haas & H.-M. Penzler

  4. Universitätsklinikum der Technischen Universität Dresden, Germany

    W.-G. Franke, R. Koch, U. Ehrenfeld, R. Haas & H.-M. Penzler

Authors
  1. W.-G. Franke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Ehrenfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Haas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H.-M. Penzler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering and Physics, University of Vienna, Dr. Heckmannstr. 4, A-1140, Vienna, Austria

    Helmar Bergmann

  2. Department of Nuclear Medicine, University of Vienna, Nadlergasse 1, A-1090, Vienna, Austria

    Helmut Sinzinger

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Birkhäuser Verlag Basel

About this chapter

Cite this chapter

Franke, WG., Koch, R., Ehrenfeld, U., Haas, R., Penzler, HM. (1995). Tumor Imaging Using a Tc-99m Labelled Immunomodulatorresults of Clinical Studies in Various Kinds of Malignant Tumors. In: Bergmann, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7340-6_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-7340-6_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7342-0

  • Online ISBN: 978-3-0348-7340-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation