Summary
Since verapamil has been shown to increase cellular concentrations of anthracyclines in resistant tumor cells, this study was designed to investigate the impact of verapamil on myocardial accumulation of I-123 labelled doxorubicin (DOX) and iodo-doxorubicin (IDOX) in rabbits and to estimate the risk of increasing anthracycline-related cardiotoxicity. Cardiac accumulation of both DOX and IDOX, calculated by scintigraphic means, neither confirmed major differences due to prior administration of verapamil nor an increased risk of cardiotoxicity of DOX and IDOX in combination with verapamil, respectively.
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References
Pastan I, Gottesman M. Multiple drug resistance in human cancer. N Engl J Med 1987; 316: 1388–1393
Damiani D, Michieli M, Michelutti A, Melli C, Cerno M, Baccarani M. D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin. Anti-Cancer Drugs 1993; 4: 173–180
Bruno NA, Slate DL. Effect of exposure to calcium entry blockers on doxorubicin accumulation and cytotoxicity in multidrug-resistant cells. J Natl Cancer Inst 1990; 82: 419424
Durie BGM, Dalton WS. Reversal of drug-resistance in multiple myeloma with verapamil. Br J Haematol 1988; 68: 203–206
Monti E, Paracchini L, Piccinini F. Effect of calcium inhibitors and calcium mobilizers on doxorubicin accumulation in rat myocardial tissue. Pharmacol Res Commun 1988; 20: 369–376
Sridhar R, Dwivedi C, Anderson J, Baker BP, Sharma HM, Desai P, Engineer FN. Effects of verapamil on the acute toxicity of doxorubicin in vivo. J Natl Cancer Inst 1992; 84: 1653–1660
Mross K, Bohn C, Edler L. Randomized phase II study of single-agent epirubicin ± verapamil in patients with advanced metastatic breast cancer. Ann Oncol 1993; 4 (1): 45–50
Wolf H, Marschall F, Scheffold N, Clausen M, Schramm M, Henze E. Iodine-123 labelling of atrial natriuretic peptide and its analoges: initial results. Eur J Nucl Med 1993; 20: 297–301.
Mross KB, Mayer U, Hamm K, Burk K, Hossfeld KD. Pharmacokinetics and metabolism of iodo-doxorubicin and doxorubicin in humans. J Clin Pharmacol 1990; 39: 507–513.
Mross K, Langenbuch T, Burk K, Hossfeld DK. Iodo-doxorubicin, ein neues Anthrazyklin-Derivat. Onkologie 1990; 13: 346–351
Villani F, Galimberti CR. Early cardiac toxicity of 4’-iodo-4’-deoxydoxorubicin. Eur J Cancer 1991; 27: 1601–1604
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© 1995 Birkhäuser Verlag Basel
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Brenner, W. et al. (1995). The Influence of Verapamil on Cardiac Uptake of I-123 Labelled Anthracyclines in Rabbits. In: Bergmann, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7340-6_63
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DOI: https://doi.org/10.1007/978-3-0348-7340-6_63
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7342-0
Online ISBN: 978-3-0348-7340-6
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