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Experimental Studies of I-123-Labelled Iodo-Doxorubicin

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Radioactive Isotopes in Clinical Medicine and Research

Part of the book series: Advances in Pharmacological Sciences ((APS))

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Summary

The aim of this study was to label iodo-doxorubicin (IDOX), a new anthracycline derivative, with I-123, and to determine its uptake both in sensitive and anthracyclineresistant tumour cell cultures compared to the unspecific tumour tracer TI-201. Iodinated iododoxorubicin showed different uptake in both cell lines. In addition pharmacokinetics of I-123IDOX was described in vivo in rabbits, revealing a myocardial uptake of labelled IDOX similar to T1-201-uptake.

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References

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Author information

Authors and Affiliations

  1. Clinic of Nuclear Medicine, Christian-Albrechts-University, Kiel, Germany

    H. Wolf, M. Schramm, K. H. Bohuslavizki, W. Brenner, M. Clausen & E. Henze

  2. Department of Nuclear Medicine, Medical Academy, Magdeburg, Germany

    A. Pethe & H.-J. Otto

Authors
  1. H. Wolf
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  2. A. Pethe
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  3. M. Schramm
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  4. K. H. Bohuslavizki
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  5. W. Brenner
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  6. M. Clausen
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  7. H.-J. Otto
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  8. E. Henze
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering and Physics, University of Vienna, Dr. Heckmannstr. 4, A-1140, Vienna, Austria

    Helmar Bergmann

  2. Department of Nuclear Medicine, University of Vienna, Nadlergasse 1, A-1090, Vienna, Austria

    Helmut Sinzinger

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© 1995 Birkhäuser Verlag Basel

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Wolf, H. et al. (1995). Experimental Studies of I-123-Labelled Iodo-Doxorubicin. In: Bergmann, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7340-6_49

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  • DOI: https://doi.org/10.1007/978-3-0348-7340-6_49

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7342-0

  • Online ISBN: 978-3-0348-7340-6

  • eBook Packages: Springer Book Archive

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