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Oxidative stress in neurobiology: An important role for iron

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Book cover Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

The brain has regions with a high iron content, and selective increases in iron occur in several neurological diseases. Low levels of intrinsic antioxidants and high levels of oxidisable substrate (polyunsaturated fatty acids) make the brain a vulnerable target for oxidative stress leading to molecular damage.

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Authors and Affiliations

  1. Oxygen Chemistry Laboratory Unit of Critical Care, Department of Anaesthesia and Intensive Care, Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London, SW3 6NP, UK

    J. M. C. Gutteridge

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  1. J. M. C. Gutteridge
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Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Gutteridge, J.M.C. (1995). Oxidative stress in neurobiology: An important role for iron. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_27

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  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_27

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7339-0

  • Online ISBN: 978-3-0348-7337-6

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