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Oxidative stress, antioxidants, aging and disease

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Oxidative Stress and Aging

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

Individuals are exposed to oxidants from before the moment of birth. Sources are both exogenous and endogenous, with the latter being mainly from “leaks” in electron transport. Various antioxidant defenses have evolved to combat the constant oxidant load, but free radical damage inevitably accumulates with age. This has led to the Free Radical Theory of Aging, first formulated by Denham Harman. The theory states that the free radical load is the cause of general aging. It may also be the cause of specific diseases associated with aging, such as heart disease, cancer, and neurodegeneration. The latter presents a good case for oxidative involvement, especially in conditions such as Parkinson’s disease. Once aging is looked at in terms of free radical processes, strategies for retarding the aging process or decreasing the likelihood of aging-related diseases become apparent. These include decreasing exposure to free radical sources and bolstering antioxidant defenses.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720-3200, USA

    L. Packer

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  1. L. Packer
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Editors and Affiliations

  1. Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    R. G. Cutler

  2. Dept. Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    L. Packer

  3. Cancer Research Center of Hawaii, Molecular Oncology, University of Hawaii at Manoa, 1236 Lauhala Street, 96813, Honolulu, HI, USA

    J. Bertram

  4. Dept. of Neuroscience, Institute of Cellular and Molecular Medicine, Okayama University, 2-5-1 Shikatacho, Okayama 700, Japan

    A. Mori

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Packer, L. (1995). Oxidative stress, antioxidants, aging and disease. In: Cutler, R.G., Packer, L., Bertram, J., Mori, A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_1

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  • DOI: https://doi.org/10.1007/978-3-0348-7337-6_1

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