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Alcohol, the reward system and dependence

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Part of the Experientia book series (EXS,volume 71)

Summary

Evidence is presented to show that multiple neurotransmitter systems of the brain reward systems including GABA, glutamate, dopamine, serotonin and opioid peptides are involved in alcohol reinforcement. Dependence is associated with changes in many of these same systems, but also with changes in other neurotransmitters, such as brain corticotropin releasing factor. A midbrain forebrain circuitry that involves parts of the nucleus accumbens and amygdala is hypothesized to be the focus for the neuropharmacology of alcohol reinforcement.

Keywords

  • Nucleus Accumbens
  • Alcohol Dependence
  • Opioid Peptide
  • Alcohol Withdrawal
  • Gamma Amino Butyric Acid

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Koob, G.F., Rassnick, S., Heinrichs, S., Weiss, F. (1994). Alcohol, the reward system and dependence. In: Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L., Vallee, B.L. (eds) Toward a Molecular Basis of Alcohol Use and Abuse. Experientia, vol 71. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7330-7_11

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  • DOI: https://doi.org/10.1007/978-3-0348-7330-7_11

  • Publisher Name: Birkhäuser Basel

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