Summary
Studies on the structure of calcium ionophore, A23187, using Infra-red, Ultraviolet, Circular dichroism, Fluorescence and Nuclear magnetic resonance methods indicated that this ionophore forms a dimer in non-polar solvents such as chloroform. When incorporated into a phospholipid vesicle, the spectra showed remarkable time dependent changes indicating further aggregation of the dimer into a stacked dimeric structure in DPPC vesicle. Results point to the possibility of A23187 transporting divalent cations across membranes by a pore rather than by a diffusive carrier model.
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© 1990 Birkhäuser Verlag Basel
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Easwaran, K.R.K., Balasubramanian, S.V. (1990). Spectroscopic Studies on the Structure and Aggregation of Calcium Ionophore, A23187. In: Vasilescu, D., Jaz, J., Packer, L., Pullman, B. (eds) Water and Ions in Biomolecular Systems. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7253-9_22
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DOI: https://doi.org/10.1007/978-3-0348-7253-9_22
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