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Pharmacology of Excitatory Amino Acid Receptors

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Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

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Summary

Excitatory amino acids such as L-glutamate are the major excitatory neurotransmitters within the mammalian central nervous system. With advances in drug development and molecular neurobiology, the pharmacology of the individual glutamate receptors and their subunits is now being more fully delineated. Described here are the characteristics of heteromeric N-methyl-D-aspartate receptors, including the actions of various selective drugs. Agents such as cyclothiazide, GYKI 52466 and novel competitive antagonists have resulted in a better understanding of the pharmacology of the α-amino-3-hydroxy-5-methylisoxazole-4-propionate subtype of glutamate receptor. Metabotropic glutamate receptors are directly coupled to second messenger systems and their pharmacological characteristics and an analysis of their link to phospholipase C are reported. Pharmacotherapy using drugs directed at glutamatergic transmission is now a very real possibility.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Monash University, Clayton, Victoria, 3168, Australia

    Dr. Philip M. Beart

  2. Novo Nordisk, 2760, Malov, Denmark

    Peter D. Suzdak

  3. CNRS UPR 9023, 34094, Montpellier Cedex 5, France

    Joel G. Bockaert

  4. Molecular Neurobiology, Salk Institute, PO Box 85800, San Diego, CA, 92186-5800, USA

    Stephen F. Heinemann

  5. Lilly Research Centre, Eri Wood Manor, Windlesham, GU20 6PH, UK

    David Lodge

Authors
  1. Dr. Philip M. Beart
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  2. Peter D. Suzdak
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  3. Joel G. Bockaert
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  4. Stephen F. Heinemann
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  5. David Lodge
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    A. Claudio Cuello  & Brian Collier  & 

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© 1995 Birkhäuser Verlag Basel/Switzerland

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Beart, P.M., Suzdak, P.D., Bockaert, J.G., Heinemann, S.F., Lodge, D. (1995). Pharmacology of Excitatory Amino Acid Receptors. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_21

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  • DOI: https://doi.org/10.1007/978-3-0348-7218-8_21

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7220-1

  • Online ISBN: 978-3-0348-7218-8

  • eBook Packages: Springer Book Archive

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