Abstract
The International Congress of Pharmacology was held in Canada for the first time and one of the symposia was entitled “Interethnic Differences in Drug Metabolism and Pharmacogenetics”. The purpose of the symposium was to discuss genetic variation of drug metabolizing enzymes in different ethnic groups. Five speakers from Sweden, Japan, USA, Canada and U.K. participated in this symposium and discussed the pharmacogenetics of drug metabolism ranging from a molecular basis to some clinical implications.
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References
Alvan G. Genetic polymorphism in drug metabolism. J. Int. Med. 1992; 231: 571–573.
Price Evans DA. Genetic factors in drug therapy — clinical and molecular pharmacogenetics. Cambridge: Cambridge University Press, 1993: 1–136.
Kalow W, Bertilsson L. Interethnic factors affecting drug response. In: Testa B, Meyer UA, editors. Advances in drug research. Vol. 25. London: Academic Press, 1994: 1–53.
Kupfer A, Preisig R. Pharmacogenetics of mephenytoin: a new hydroxylation polymorphism in man. Eur. J. Clin. Pharmacol. 1984; 26: 753–759.
Inaba T. Pharamcogenetic polymorphism: mephenytoin hydroxylation deficiency. In: Kato R, Estabrook RW, Cayen MN, (editors), Xenobiotic metabolism and disposition. London: Talor & Francis, 1989: 467–474.
Beischlag TV, Kalow W, Mahon WA, Inaba T. Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin. Xenobiotica 1992; 22: 559–567.
Yasumori T, Li Q-H, Yamazoe Y, Ueda M, Tsuzuki T, Kato R. Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4′-hydroxylation. Pharmacogenetics. 1994; 4: 323–331.
Goldstein JA, Faletto MB, Romkes-Sparks M, Sullivan T, Kitareewan S, Raucy JL, Lasker JM, Ghanayem BI. Evidence that CYP2C19 is the major S-mephenytoin 4′-hydroxylase in humans. Biochemistry 1994; 33: 1743–1752.
de Morais SMF, Wilkinson GR, Blasidell J, Nakamura K, Meyer UA, Goldstein JA. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem. 1984; 269: 15419–15422.
de Morais SMF, Wilkinson GR, Blasidell J, Meyer UA, Nakamura K, Goldstein JA. Identification of a new genetic defect responsible for the polymorphism of S-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994; 46: 594–598.
Inaba T, Someya T, Shibasaki M, Tang SW, Takahashi S. Influence of ethnicity on reduced haloperidol concentrations in blood. In: Lin KM et al. (editors), Psychopharmacology and psychobiology of ethnicity. Washington: Am. Psychiatric Press, 1993: 123–132.
Someya T, Takahashi S, Shibasaki M, Inaba T, Cheung SW, Tang SW. Reduced haloperidol/haloperidol ratios: polymorphism in Japanese psychiatric patients. Psychiatry Res. 1990; 31: 111–120.
Butler MA, Lang NP, Young JF, Caporaso NE, Vineis P, Hayes RB, Teitel CH, Massengi JP, Lawsen MF, Kadlubar FF. Determination of CYP1A2 and NAT2 pheno-types in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 1992; 2: 116–127.
Notarianni LJ, Oliver SE, Dobrocky P, Bennett PN, Silverman BW. Caffeine as a metabolic probe: A comparison of the metabolic ratios used to assess CYP1A2 activity. Brit. J. Clin. Pharmacol. In press.
Tucker GT, Rostami-Hodjegan A, Nurminen S, Jackson PR. (1994) In preparation.
Campbell ME, Spielberg SP, Kalow W. A urinary metabolite ratio that reflects systemic caffeine clearance. Clin. Pharmacol. Ther. 1987; 42: 157–165.
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© 1995 Birkhäuser Verlag Basel/Switzerland
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Inaba, T. et al. (1995). Interethnic Differences in Drug Metabolism and Pharmacogenetics. In: Cuello, A.C., Collier, B. (eds) Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7218-8_17
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DOI: https://doi.org/10.1007/978-3-0348-7218-8_17
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