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Recent advances in benzodiazepine receptor (BZR) binding studies

  • Chapter
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques

Abstract

The discovery of benzodiazepines (BZs) 1and their receptors have opened a new era in the discovery and characterization of drugs acting on the central nervous system (CNS). The pioneering and explorative synthetic work

of Sternbach in the early days of the BZ era led to the development of compound 2with its unusual pharmacological profile. The story of its development as narrated by Sternbach himself is very interesting [1a-c]. While its structure was studied by Sternbach and Reeder [1d], its sophisticated pharmacological tests were done by Randall and his staff [2]. It was given the generic name chlordiazepoxide and was launched under the trade name Librium®. The synthesis of this compound was rapidly followed by its derivative diazepam 3, which was given the trade name Valium®. These two drugs, which appeared on the market in rapid succession, soon became the most frequently prescribed CNS drugs. The success of these two drugs led Sternbach and his group to synthesize a number of related products (for examples see papers in ref. [3]) and, by the end of 1983, about 35 benzodiazepine drugs were available for therapy. The BZ drugs have a wide range of therapeutic applications [4].

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  1. Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031, India

    S. P. Gupta

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    E. Jucker

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    E. Jucker

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© 1995 Birkhäuser Verlag, Basel (Switzerland)

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Gupta, S.P. (1995). Recent advances in benzodiazepine receptor (BZR) binding studies. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 45. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7164-8_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7164-8_3

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