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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques pp 409–465Cite as

Agents acting on central dopamine receptors

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Abstract

Dopamine was long believed to be only of functional significance as a precursor of epinephrine and norepinephrine. It became a focus of interest only after Carlsson’s [1] demonstration of its presence in relatively high concentrations in various parts of the brain, mainly striatum [2] and inner retina [3]. Since then there is a growing evidence of the involvement of dopamine as an important neurotransmitter and of the clinical significance of dopaminergic transmission in CNS. It has been suggested that degeneration of the dopaminergic pathway that connects substantia nigra to the caudate nucleus and putamen is a primary feature in the etiology of Parkinson’s disease [4, 5]. Similarly, dopaminergic system has been implicated in the treatment of schizophrenia with antipsychotic drugs [6]. Dopamine agonists and antagonists are thus antiparkinsonian and antipsychotic drugs, respectively, due to their action on central dopamine receptors [7].

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  1. Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, 226001, India

    Naresh Kumar & Padam C. Jain

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    Ernst Jucker

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Kumar, N., Jain, P.C. (1977). Agents acting on central dopamine receptors. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 21. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7098-6_5

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