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The Levamisole Story

  • Chapter
Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques

Abstract

In the early 1960s our laboratory was engaged in a research program designed to find a superior anthelmintic drug. We wanted it to be chemically unrelated to known drugs, potent, safe, economical, injectable, active against larval stages and active against as wide a variety of worms as possible. Lacking any adequate chemical lead on which to base development of a new drug, we synthesized many new and relatively simple heterocyclic compounds, which we then evaluated for anthelmintic activity against ascarids, heterakids and capillarids in a critical test using naturally infected chickens. For quite some time, however, it looked as if we were climbing trees to seek fish, because the standard oral dose (160 mg/kg) of the 2,721 first compounds thus tested invariably turned out to be ineffective. The next compound however, the aminothiazole derivative I, R6438, turned the tide in our favor: it was capable of removing the three nematode species from the gastrointestinal tract of three chickens.

Our labors are in vain — all the manifold contributions of science, the incessant researches into the complex problems of life, normal or perverted, the profound and far-reaching conclusions of the thinkers and originators — all these are Nehushtan, sounding brass and tinkling cymbals, unless they result in making man better able to fight the battle against disease, better equipped for their ministry of healing. W. Osier (1907)

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  1. Janssen Pharmaceutica, B-2340, Beerse, Belgium

    Dr. Paul A. J. Janssen M.D., C.Sc.N., Aggr. Pharmacol.

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  1. Dr. Paul A. J. Janssen M.D., C.Sc.N., Aggr. Pharmacol.
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    Ernst Jucker

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Janssen, P.A.J. (1976). The Levamisole Story. In: Jucker, E. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques, vol 20. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7094-8_11

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