Recent advances in molecular and cellular biology have upgraded the idea of clinical human gene therapy from mere speculation to a clear possibility. The concept of gene therapy is about attacking human disease at the level of underlying genetic mechanisms and defects. As Aposhian stated, in 1970, “If one considers the purpose of a drug to restore the normal function of some particular process in the body, then DNA would be considered the ultimate drug” . Implementation of the concept of DNA as an ultimate drug has involved, among other important aspects, development of gene delivery vehicles, optimization of gene delivery methods and studies to determine stability and expression of the desired gene. In this regard, a number of gene delivery systems, as described in earlier chapters, have been tried. Use of liposomes as a gene transfer method is the focus of this chapter but representation of their role deserves a detailed introduction. Therefore this article describes their preparation and role as a vehicle to deliver DNA molecules and the possible delivery mechanism of encapsulated materials.
- Gene Therapy
- Gene Delivery
- Cationic Liposome
- Sendai Virus
- Liposome Preparation
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Bagasra, O., Amjad, M., Mukhtar, M. (1999). Liposomes in Gene Therapy. In: Blankenstein, T. (eds) Gene Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7011-5_5
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Print ISBN: 978-3-0348-7013-9
Online ISBN: 978-3-0348-7011-5
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