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Adenovirus Vectors for Gene Therapy

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Gene Therapy

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Abstract

In the fast growing area of vector systems, one of the most advanced is the replication deficient-recombinant adenovirus (Ad vector). It is remarkably efficient at transferring genes to a wide variety of target cells in vitro and in vivo and at ex­pressing exogenous genes at a high level [Crystal, 1995; Horwitz, 1996]. After in­fection, the Ad vector expresses the transgene in the nucleus of replicating and non-replicating cells in an epi-chromosomal fashion, where the duration of gene expres­sion is transient over time [Rosenfeld et al., 1991; Kass-Eissler et al., 1994; Smith et al., 1993; Engelhard et al., 1994; Yang et al., 1994a, b].

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  1. G. Wolff
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  1. Max-Delbrück-Centrum für molekulare Medizin, Robert-Rössle-Strasse 10, D-13122, Berlin-Buch, Germany

    Thomas Blankenstein

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Wolff, G. (1999). Adenovirus Vectors for Gene Therapy. In: Blankenstein, T. (eds) Gene Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7011-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7011-5_3

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