Abstract
In recent years, techniques involving subcutaneous implanation of sponges have become a popular means for studying angiogenesis. For example, polyvinyl alcohol sponges have been used to quantitate the effects of cartilage derived growth factor [1] and epidermal growth factor [2] on the DNA, protein, collagen and hydroxyproline content of the implants. In another study, double velour Dacron sponges were used to induced neovascularisation which was then assessed by light microscopy, autoradiography, electron microscopy and angiography [3]. More recently, a disc angiogenesis system was devised, incorporating ethylene-vinyl acetate co-polymer to facilitate sustained release of angiogenic agonists and antagonists [4]. These various sponge models are therefore amenable to biochemical and morphological analyses to provide valuable information on the control mechanisms on angiogenesis. However, such analyses can only be carried out post mortem.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Fan, TP.D., Hu, DE., Smither, R.L., Gresham, G.A. (1992). Further studies on angiogenesis in a rat sponge model. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_49
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_49
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