Abstract
Angiogenesis plays an important role in a variety of physiological and pathological processes such as embryogenesis, wound healing and tumour growth. Although vascular smooth muscle cells and pericytes take part in angiogenesis, endothelial cells are considered to be the critical component in neovascularisation [1]. The migration and proliferation of endothelial cells are the two key events that occur in angiogenesis [2–4]. Furthermore, monoclonal antibodies against endothelial cells have been raised in an attempt to identify the process of angiogenesis [5–7]. A clearer understanding of the role of endothelial cells in angiogenesis will contribute to the control of angiogenic diseases [8, 9]. In the present report, we describe a monoclonal antibody E-9, which binds preferen-tially to the vasculature in human tumours, embryonic and regenerating tissues.
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References
Folkman J: What is the role of endothelial cells in angiogensis? Lab Invest 1984; 51: 601–604.
Ausprunk DH, Folkman J Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977; 14: 53–65.
Denekamp J, Hobson B: Endothelial cell proliferation in experimental tumours. Br J Cancer 1982; 46: 711–720.
Hirst DG, Denekamp J, Hobson B: Proliferation kinetics of endothelial and tumour cells in three mouse mammary carcinomas. Cell Tissue Kinet 1982; 15: 251–261.
Hagemeier HH, Vollmer E, Goerdt S, Osthoff KS, Sorg C: A monoclonal antibody reacting with endothelial cells of budding vessels in tumours and inflammatory tissues, and non-reactive with normal adult tissues. Int J Cancer 1989; 38: 481–488.
Schlingemann RO, Dingjan GM, Emeis JJ, Blok J, Warnaar SO, Ruiter DJ: Monoclonal antibody PAL-E specific for endothelium. Lab Invest 1985; 52: 71–76.
Ramani P, Bradley NJ, Fletcher CDM: QBEB/10, a new monoclonal antibody to endothlium: assessment of its diagostic utility in paraffin sections. Histopathology 1990; 17: 237–242.
Folkman J: What is the evidence that tumors are angiogenesis dependent? JNCL 1990; 82: 4–6.
Denekamp J: Endothelial cell proliferation as a novel approach to targeting tumour therapy: Br J Cancer 1982; 45: 136–139.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Wang, J.M., Hunter, R.D., Kumar, S. (1992). A monoclonal antibody (E-9) binds preferentially to the vasculatures of human tumors, embryonic and regenerating tissues. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_42
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_42
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7003-0
Online ISBN: 978-3-0348-7001-6
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