Abstract
Angiogenesis plays an important role in a variety of physiological and pathological processes such as embryogenesis, wound healing and tumour growth. Although vascular smooth muscle cells and pericytes take part in angiogenesis, endothelial cells are considered to be the critical component in neovascularisation [1]. The migration and proliferation of endothelial cells are the two key events that occur in angiogenesis [2–4]. Furthermore, monoclonal antibodies against endothelial cells have been raised in an attempt to identify the process of angiogenesis [5–7]. A clearer understanding of the role of endothelial cells in angiogenesis will contribute to the control of angiogenic diseases [8, 9]. In the present report, we describe a monoclonal antibody E-9, which binds preferen-tially to the vasculature in human tumours, embryonic and regenerating tissues.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Wang, J.M., Hunter, R.D., Kumar, S. (1992). A monoclonal antibody (E-9) binds preferentially to the vasculatures of human tumors, embryonic and regenerating tissues. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_42
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_42
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7003-0
Online ISBN: 978-3-0348-7001-6
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