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Basic fibroblast growth factor bound to cell substrate promotes cell adhesion, proliferation, and protease production in cultured endothelial cells

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Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 61))

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Abstract

The extracellular matrix (ECM) plays a crucial role in the process of endothelial cell migration, proliferation, and differentiation during angiogenesis [1]. Several ECM proteins, like fibronectin (FN), affect cell behavior by binding to the various members of the integrin family of receptors, molecules that recognize the cell adhesion signal sequence Arg-Gly-Asp (RGD) [2].

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References

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Author information

Authors and Affiliations

  1. Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123, Brescia, Italy

    Marco Presta, Marco Rusnati, Chiara Urbinati, Elena Tanghetti, Massimo Statuto, Ambra Pozzi, Anna Gualandris & Giovanni Ragnotti

Authors
  1. Marco Presta
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  2. Marco Rusnati
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  3. Chiara Urbinati
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  4. Elena Tanghetti
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  5. Massimo Statuto
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  6. Ambra Pozzi
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  7. Anna Gualandris
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  8. Giovanni Ragnotti
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Editor information

Editors and Affiliations

  1. Research Division, Dept. of Surgery, University Hospital Zurich, 8091, Zurich, Switzerland

    Rudolf Steiner

  2. Dept. of Chemical and Bioengineering, University of Pennsylvania, Room 312, Towne Building/D3, 19104, Philadelphia, PA, USA

    Paul B. Weisz

  3. Dept. of Chemical Engineering and Harvard — MIT Division of Health, Science and Technology, Massachusetts Institute of Technology, Building E 25 Room 342, 02139, Cambridge, MA, USA

    Robert Langer

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Presta, M. et al. (1992). Basic fibroblast growth factor bound to cell substrate promotes cell adhesion, proliferation, and protease production in cultured endothelial cells. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_31

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_31

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

  • eBook Packages: Springer Book Archive

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