Abstract
The cardiac physiology and neurochemistry of bivalve molluscs have been under intensive investigation for the past 25 years or so. Hand in hand with these studies, a generalized outline of the pharmacology of four presumed neurotransmitter substances on the hearts of these animals has emerged. Most of this conceptual outline was developed in the laboratory of Professor John H. Welsh with the heart of the quahog Mercenaria (= Venus) mercenaria as the primary experimental object.
now (more near ourselves than we)
is a bird singing in a tree,
who never sings the same thing twice
and still that singing’s always his1
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Research supported by grants from the U.S.P.H.S. (HE-09283; National Heart Institute); N.S.F. (Senior Postdoctoral Fellowship); and the U.S.A.E.C. (Div. of Biology and Medicine). I wish to thank the staffs of the marine laboratories at Friday Harbor (University of Washington), Alligator Harbor (Florida State University), Heron Island (Great Barrier Reef Committee), and Misaki (Tokyo University) where much of this work was done. I am in debt to Dr. R. Bircher (dec.) (Sandoz Pharmaceuticals) for supplying UML-491 and BOL-148, and to Dr. A. M. Lands (Sterling-Winthrop Research Institute) for Mytolon chloride (benzoquinonium).
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Greenberg, M.J. (1969). The Role of Isoreceptors in the Neurohormonal Regulation of Bivalve Hearts. In: McCann, F.V. (eds) Comparative Physiology of the Heart: Current Trends. Experientia Supplementum. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6800-6_23
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DOI: https://doi.org/10.1007/978-3-0348-6800-6_23
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