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Metallothionein II pp 401–405Cite as

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Transcriptional Control Mechanisms Which Regulate the Expression of Human Metallothionein Genes

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Part of the book series: Experientia Supplementum ((EXS,volume 52))

Abstract

The human genome contains at least 12 distinct metallothionein genes. The expression of these genes is regulated at the transcriptional levels by heavy metal ions, steroid hormones, interferon, interleukin 1 and phorbol esters. Comparisons of metallothionein gene sequences reveals a higher level of heterogeneity in the 5′ flanking control regions than in the coding regions. This is due to the presence of distinct promoter elements on each of the genes. These elements are responsible for inducer and tissue specificity of metallothionein gene expression.

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Author information

Authors and Affiliations

  1. Department of Microbiology, University of Southern California School of Medicine, Los Angeles, CA, 90033, USA

    Prof. Michael Karin, Alois Haslinger, Adriana Heguy, Therese Dietlin & Richard Imbra

  2. Department of Microbiology, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA, 90033, USA

    Prof. Michael Karin

Authors
  1. Prof. Michael Karin
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  2. Alois Haslinger
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  3. Adriana Heguy
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  4. Therese Dietlin
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  5. Richard Imbra
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Editor information

Editors and Affiliations

  1. Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Jeremias H. R. Kägi

  2. Dept. of Environmental Medicine, Hokkaido University, Kita-ku, Sapporo, 060, Japan

    Yutaka Kojima

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© 1987 Springer Basel AG

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Karin, M., Haslinger, A., Heguy, A., Dietlin, T., Imbra, R. (1987). Transcriptional Control Mechanisms Which Regulate the Expression of Human Metallothionein Genes. In: Kägi, J.H.R., Kojima, Y. (eds) Metallothionein II. Experientia Supplementum, vol 52. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6784-9_38

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  • DOI: https://doi.org/10.1007/978-3-0348-6784-9_38

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6786-3

  • Online ISBN: 978-3-0348-6784-9

  • eBook Packages: Springer Book Archive

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