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A Potential Animal Model for the Study of Anti-Panic Treatments

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Book cover Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

The effects of long-term chronic post-test treatment with numerous typical (e.g., imipramine, desipramine, phenelzine) or atypical (alprazolam, trazodone, mianserin, buproprion) antidepressants on conflict behaviour in rats were determined. Chronic treatment with most agents (exceptions: mianserin, buproprion) resulted in a gradually-developing anti-conflict effect, with a latency to onset of 3–5 weeks. These data suggest that animal conflict paradigms might be effective animal procedures for studying the anxiolytic and/or anti-panic effects of antidepressant agents.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State University, Detroit, Michigan, 48202, USA

    R. L. Commissaris & D. J. Fontana

Authors
  1. R. L. Commissaris
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  2. D. J. Fontana
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Editor information

Editors and Affiliations

  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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© 1991 Springer Basel AG

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Commissaris, R.L., Fontana, D.J. (1991). A Potential Animal Model for the Study of Anti-Panic Treatments. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_5

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6421-3

  • Online ISBN: 978-3-0348-6419-0

  • eBook Packages: Springer Book Archive

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