Abstract
The pain-alleviating property of dipyrone has been demonstrated in numerous studies [1]. However, only a small number of approaches try to establish the analgesic action of dipyrone quantitatively by means of experimental pain models [2][3][4]. Even the technique of pain-related evoked potentials, when employed in this field, yielded only unsatisfactory results (reviewed by [5]). It is quite conceivable that this is due to the fact that in most cases phasic painful stimuli were used without an actual inflammatory process being present. Under such conditions the non-steroidal anti-inflammatory drugs (NSAIDs), in particular, are able to develop only a small part of their analgesic efficacy.
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Kobal, G., Huber, H., Pauli, E., Hummel, T. (1990). Testing the analgesic activity of dipyrone in human subjects using an experimental pain model with tonic and phasic pain stimuli. In: Brune, K. (eds) New Pharmacological and Epidemiological Data in Analgesics Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6387-2_3
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DOI: https://doi.org/10.1007/978-3-0348-6387-2_3
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